User:Mr. Ibrahem/sandbox

From WikiProjectMed
Jump to navigation Jump to search
Mr. Ibrahem/sandbox
Names
Trade namesStelazine, Eskazinyl, Eskazine, Jatroneural, others
  • 10-[3-(4-methylpiperazin-1-yl)propyl]-
    2-(trifluoromethyl)-10H-phenothiazine
Clinical data
Drug classTypical antipsychotic
Main usesSchizophrenia, generalized anxiety disorder, nausea[1][2]
Side effectsMovement disorders, sleepiness, blurry vision, dry mouth, low blood pressure[1][3]
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
use
By mouth, IM
External links
AHFS/Drugs.comMonograph
MedlinePlusa682121
Legal
Legal status
Pharmacokinetics
MetabolismLiver
Elimination half-life10–20 hours
Chemical and physical data
FormulaC21H24F3N3S
Molar mass407.50 g·mol−1
3D model (JSmol)
  • FC(F)(F)c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4
  • InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3 checkY
  • Key:ZEWQUBUPAILYHI-UHFFFAOYSA-N checkY

Trifluoperazine, sold under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia.[1] It is also used, short term, for generalized anxiety disorder but is less preferred to benzodiazepines and use for nausea.[1][2] It is taken by mouth.[1]

Common side effects include movement disorders including tardive dyskinesia, sleepiness, blurry vision, dry mouth, and low blood pressure.[1][3] Other severe side effects may include neuroleptic malignant syndrome, pancytopenia, and liver problems.[1] It increases the risk of death in those with dementia.[1] It is in the phenothiazine chemical class.[3] It is believed to work by blocking the effects of dopamine.[1]

Trifluoperazine was patented in 1955 and came into medical use in 1959.[3] It is available as a generic medication.[2] In the United States a month of medication at 5 mg twice per day costs about 27 USD as of 2021.[4] This amount in the United Kingdom costs the NHS about £83.[2]

References

[2]

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Trifluoperazine Monograph for Professionals". Drugs.com. Archived from the original on 7 August 2017. Retrieved 19 September 2021.
  2. 2.0 2.1 2.2 2.3 2.4 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 408. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  3. 3.0 3.1 3.2 3.3 Buschmann, Helmut; Holenz, Jörg; Párraga, Antonio; Torrens, Antoni; Vela, José Miguel; Díaz, José Luis (16 April 2007). Antidepressants, Antipsychotics, Anxiolytics, 2 Volume Set: From Chemistry and Pharmacology to Clinical Application. John Wiley & Sons. p. 508. ISBN 978-3-527-31058-6. Archived from the original on 22 September 2021. Retrieved 19 September 2021.
  4. "Trifluoperazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 September 2021.