User:Mr. Ibrahem/sandbox
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Names | |
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Trade names | Stelazine, Eskazinyl, Eskazine, Jatroneural, others |
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Clinical data | |
Drug class | Typical antipsychotic |
Main uses | Schizophrenia, generalized anxiety disorder, nausea[1][2] |
Side effects | Movement disorders, sleepiness, blurry vision, dry mouth, low blood pressure[1][3] |
Pregnancy category |
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Routes of use | By mouth, IM |
External links | |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682121 |
Legal | |
Legal status | |
Pharmacokinetics | |
Metabolism | Liver |
Elimination half-life | 10–20 hours |
Chemical and physical data | |
Formula | C21H24F3N3S |
Molar mass | 407.50 g·mol−1 |
3D model (JSmol) | |
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Trifluoperazine, sold under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia.[1] It is also used, short term, for generalized anxiety disorder but is less preferred to benzodiazepines and use for nausea.[1][2] It is taken by mouth.[1]
Common side effects include movement disorders including tardive dyskinesia, sleepiness, blurry vision, dry mouth, and low blood pressure.[1][3] Other severe side effects may include neuroleptic malignant syndrome, pancytopenia, and liver problems.[1] It increases the risk of death in those with dementia.[1] It is in the phenothiazine chemical class.[3] It is believed to work by blocking the effects of dopamine.[1]
Trifluoperazine was patented in 1955 and came into medical use in 1959.[3] It is available as a generic medication.[2] In the United States a month of medication at 5 mg twice per day costs about 27 USD as of 2021.[4] This amount in the United Kingdom costs the NHS about £83.[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Trifluoperazine Monograph for Professionals". Drugs.com. Archived from the original on 7 August 2017. Retrieved 19 September 2021.
- ↑ 2.0 2.1 2.2 2.3 2.4 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 408. ISBN 978-0-85711-369-6.
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: CS1 maint: date format (link) - ↑ 3.0 3.1 3.2 3.3 Buschmann, Helmut; Holenz, Jörg; Párraga, Antonio; Torrens, Antoni; Vela, José Miguel; Díaz, José Luis (16 April 2007). Antidepressants, Antipsychotics, Anxiolytics, 2 Volume Set: From Chemistry and Pharmacology to Clinical Application. John Wiley & Sons. p. 508. ISBN 978-3-527-31058-6. Archived from the original on 22 September 2021. Retrieved 19 September 2021.
- ↑ "Trifluoperazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 September 2021.