Triple dye
Triple dye is an antiseptic initially used for the treatment of burn victims during the Second World War. It later came into use in general medicine. A commercial implementation was as a constituent of "over-the-counter" antiseptic soaps and handwashes.
Compound
The active ingredients of the compound, with typical percentages by weight, are:
- brilliant green 0.77%
- proflavine 0.58%
- gentian violet 1.17%
History
The preparation was initially used for the treatment of burn victims during the Second World War.[2][1][3] Application was as a 50% mixture with soft soap solution.[4] Later, it was adopted in dentistry for the treatment of severe gum disease.[5] Commercially, it came into use as an ingredient of "over-the-counter" antiseptic handwashes and medicated soap.[6] Today, it remains in widespread use in midwifery, for application to the umbilicus of newborn infants.[7]
In September 2016 the Food and Drug Administration of the United States, while not restricting the product's applications in medicine, ruled that the available data regarding uptake and retention of triple dye in the bodies of long-term users were insufficient to show that it could be "Generally recognized as safe and effective" and its sale as a consumer product was terminated.[6]
References
- ^ a b Creagh, Gerard R. (January 1943). "Battle Casualties Aboard a Light Cruiser". United States Naval Medical Bulletin. XLI (4): 939.
- ^ Smyth, Calvin M. (1943). Piersol, George Morris (ed.). "Modern Treatment of Burns". Clinics. 2 (1). Philadelphia: J.B. Lippincott: 210.
- ^ Atkins, H. J. B. (1942). "War Surgery Of The Extremities: The Management Of Burns (Concluded)". The British Medical Journal. 1 (4249): 729–731. ISSN 0007-1447. JSTOR 20323395.
- ^ Cope, Zachary, ed. (1953). Surgery. London: HMSO. p. 294. OCLC 559262204.
- ^ Buchin, Irving (August 1945). "Drugs in treatment of periodontal disease". The Bulletin of the U. S. Medical Department. IV (2). Washington, DC: 212.
- ^ a b Wolf, Kevin J (6 September 2016). "Safety and Effectiveness of Consumer Antiseptics; Topical Antimicrobial Drug Products for Over-the-Counter Human Use". Federal Register. 81 (172): 61106–61130.
- ^ Roth, Philip (2011). "Neonatology". Pediatric Secrets: 423–479. doi:10.1016/B978-0-323-06561-0.00012-4. ISBN 9780323065610.
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