Template:Side effects of combined androgen blockade with nilutamide and surgical castration
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| Class | Side effect | Nilutamide 150 mg/day + orchiectomy (n = 225) (%)a,b |
Placebo + orchi- ectomy (n = 232) (%)a,b |
|---|---|---|---|
| Cardiovascular system | Hypertension | 5.3 | 2.6 |
| Digestive system | Nausea | 9.8 | 6.0 |
| Constipation | 7.1 | 3.9 | |
| Endocrine system | Hot flashes | 28.4 | 22.4 |
| Metabolic and nutritional system | Increased aspartate transaminase | 8.0 | 3.9 |
| Increased alanine transaminase | 7.6 | 4.3 | |
| Nervous system | Dizziness | 7.1 | 3.4 |
| Respiratory system | Dyspnea | 6.2 | 7.3 |
| Special senses | Impaired adaptation to darkness | 12.9 | 1.3 |
| Abnormal vision | 6.7 | 1.7 | |
| Urogenital system | Urinary tract infection | 8.0 | 9.1 |
| Overall | 86 | 81 | |
| Footnotes: a = Phase III studies of combined androgen blockade (nilutamide + orchiectomy) in men with advanced prostate cancer. b = Incidence ≥5% regardless of causality. Sources: [1] | |||
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