Template:Glucocorticoid activity of selected steroids in vitro
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Steroid | Class | TR (↑)a | GR (%)b |
---|---|---|---|
Dexamethasone | Corticosteroid | ++ | 100 |
Ethinylestradiol | Estrogen | – | 0 |
Etonogestrel | Progestin | + | 14 |
Gestodene | Progestin | + | 27 |
Levonorgestrel | Progestin | – | 1 |
Medroxyprogesterone acetate | Progestin | + | 29 |
Norethisterone | Progestin | – | 0 |
Norgestimate | Progestin | – | 1 |
Progesterone | Progestogen | + | 10 |
Footnotes: a = Thrombin receptor (TR) upregulation (↑) in vascular smooth muscle cells (VSMCs). b = RBA (%) for the glucocorticoid receptor (GR). Strength: – = No effect. + = Pronounced effect. ++ = Strong effect. Sources: [1] |
References
- ↑ Kuhl H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration" (PDF). Climacteric. 8 Suppl 1: 3–63. doi:10.1080/13697130500148875. PMID 16112947.