Talk:Zinc L-carnosine

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Safety. How long were the longest clinical studies in days, weeks, months or years?

How many patients were studied? And which blood tests were done? ee1518 (talk) 12:04, 10 November 2017 (UTC)[reply]

Please follow the references, although you would want to look at primary references, not the secondary ones used in the article. The primary references cannot be used to write the article. Pretty much your only safety concern, IMHO, with the ~30mg dose is copper depletion, and that is trivially addressable with a 2mg or 4mg copper (as glycinate) supplement. I later decreased zinc (as carnosine) to half the dose, i.e. 16mg, purely for maintenance. If I take a NSAID, I then take an extra 8mg for two days. At the 16mg dose the copper is less essential, but I take it anyway. As for L-carnosine, it is studied in much higher doses, i.e. multiples of 500mg, so you've nothing to worry about there. Note that zinc carnosine is not a pharmaceutical; you've little to worry about. Both zinc and carnosine exist individually in diets. --Acyclic (talk) 15:21, 10 November 2017 (UTC)[reply]

In which countries this is sold at pharmacies? Optimal dosage?

  • Pharmacies:

This Wikipedia article is in English only. What is the translation in other European languages? in Spanish, German?

Is this sold at pharmacies in Germany, Spain, other European countries?

Tablet or powder might be the ideal dosage form, as then it would have local benefits in mouth and esophagus. Not only in stomach and intestines.

I suppose at least in USA and India this is available at pharmacies.

  • Dosage (in lifetime use):

Have different dosages been compared in any clinical study?

Has twice-daily dosage been proven better than once-daily?

ee1518 (talk) 09:41, 21 January 2019 (UTC)[reply]

There is no available translation that I am aware of, but obviously you can try using Google Translate, etc. It is definitely sold online as a supplement, at least in the USA, but not in pharmacies. It is also sold on Amazon as a lozenge like form which I haven't yet tried. If you can't find it in Europe, you can import it from the US. Given the research, indeed I consider the powder, lozenge, and gel forms to be more efficacious than a swallowed capsule or tablet. I don't expect it'll help the large intestine. Twice daily is definitely better. Initially I used 16 mg zinc twice daily, but now I use 8 mg zinc twice daily. Note that the dose is already documented in the article. We cannot engage in giving medical advice on Wikipedia. --Acyclic (talk) 13:47, 21 January 2019 (UTC)[reply]

Patent claim

https://www.ncbi.nlm.nih.gov/pubmed/10951100 is not a valid reference for the patent claim. Its full text at http://protein.bio.msu.ru/biokhimiya/contents/v65/full/65070961.html makes no mention of the patent. A MEDRS compatible published review article which makes the patent claim is required to allow the patent claim. --Acyclic (talk) 21:56, 26 June 2019 (UTC)[reply]

Effectiveness - studies from other mammals

Several studies carried out in dogs show no evidence of benefit in various gastrointestinal disorders, gastroduodenal damage (ulcers) or other artificial damage to the mucosa. I think it should be added to the article to contrast other evidence, however I don't feel confident enough about editing and the rules of Wikipedia so I'd appreciate if other people could give some feedback on this matter, check the research and take appropriate action.

My sources for the above claims:

Kastheus (talk) 23:08, 5 December 2023 (UTC)[reply]

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