User talk:Acyclic
The lowest published lethal human oral dose of DNP is 4.3 mg/kg
Dear Acyclic,
You have "Undid revision 845428389 by VaioG. Misleading because this required weeks of dosing. Please specify the lowest dose over its full period, and include mention of the period in days or weeks."
It's not misleading:
"Ingestion is currently the most common route of exposure to the drug leading to death. The lowest published lethal human oral dose of DNP is 4.3 mg/kg [76]; the doses reported in the published acute and suicidal fatalities range from 2.8 g to an estimated 5 g. The highest reported dose taken in acute overdose associated with survival was a woman who took 2.4 g with no complications [70]."2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death PMID: 21739343. Furthermore, in the 'Oxford Desk Reference: Toxicology edited by Nick Bateman, Robert Jefferson, Simon Thomas, John Thompson, Allister Vale' published in 2014- "The lowest published lethal ingested dose is 4.3mg/kg; the highest reported dose associated with survival was a woman who took 2.4g with no complications."Oxford Desk Reference: Toxicology
However, "In studies of intermediate-duration oral exposure to 2,4-DNP, cases of death from agranulocytosis (described in the discussion of Hematological Effects) have been attributed to 2,4-DNP. These cases occurred during the usual dosing regimens for weight loss, employing increasing doses in one case from 2.9 to 4.3 mg/kg/day of 2,4-DNP for 6 weeks (Dameshek and Gargill 1934); a dose of 1.03 mg/kg/day 2,4-DNP for 46 days in another case (Goldman and Haber 1936); and in another, from 0.62 to 3.8 mg/kg/day 2,4-DNP as sodium 2,4-DNP for 41 days (Silver 1934)."https://www.atsdr.cdc.gov/toxprofiles/tp64-c2.pdf
Kind Regards VaioG (talk) 19:31, 14 June 2018 (UTC)
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