Talk:Zanamivir

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Zanamivir.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

History

The history cited in this article conflicts with other histories available online, such as that at the CSIRO website (http://www.csiro.au/solutions/Relenza.html). For example it incorrectly cites Colman and Laver as the discoverers of Zanamivir, when in fact they identified the static neuraminidase protein that occurs in all strains of influenza. Von Itzstein's team discovered the molecule, Zanamivir, that blocks that protein. Thus it's von Itzstein who is credited as the discoverer of Relenza. Also, Biota didn't fund the initial research into the discovery of the neuraminidase, only the discovery of Zanamivir.

Other histories might need to be checked to clarify this section. Tczuel (talk) 00:35, 11 August 2009 (UTC)[reply]

I've restored the material surrounding von Itzstein's role, which had been removed about a week ago. Emw2012 (talk) 16:41, 12 August 2009 (UTC)[reply]

Bird Flu

According to a new study, it might be of help against the feared H5N1:

"This research points to swift and effective use of antivirals, such as Tamiflu or Relenza, in order to prevent virus levels from rising too fast."

    http://www.medicalnewstoday.com/healthnews.php?newsid=51587

-- MyrddinEmrys 23:56, 11 September 2006 (UTC)[reply]

Progression of Relenza

Paragraphs 3 and 4 of this section (the ones starting "Computational chemistry techniques to probe the active site of the enzyme" and "The strategy relied on the availability") are a mess. They contain random italics, some asterisks, and sentences that don't make sense. I'm pretty sure that some of this section may have been copied from a paper with "we" replaced by "they". Can someone who knows what they're talking about fix this please? Baratron (talk) 20:43, 29 March 2009 (UTC)[reply]

Relation to Swine Flu

I have seen articles that indicate this drug as being used to treat swine flu w/ success (along w/ Tamiflu). I was surprised to see no reference to it in the article. Todd (talk) 11:26, 28 April 2009 (UTC)[reply]

Proposing deletion of most of 'Development' section

In my opinion, the Development section contains a lot of background information that isn't immediately relevant to zanamivir. For example, it doesn't seem necessary to go into detail about the background of influenza (as the first paragraph of the Background section does -- the same goes for influenza A or B. Unless some cogent arguments to keep these sections are forwarded within the next three days, I plan on removing the irrelevant details and merging the relevant content about zanamivir into other sections. Cheers, Emw2012 (talk) 20:12, 28 April 2009 (UTC)[reply]

Copyright problem removed

One or more portions of this article duplicated other source(s). The material was copied from: http://www.nature.com/nm/journal/v11/n9/full/nm0905-909.html. Infringing material has been rewritten or removed and must not be restored, unless it is duly released under a compatible license. (For more information, please see "using copyrighted works from others" if you are not the copyright holder of this material, or "donating copyrighted materials" if you are.) For legal reasons, we cannot accept copyrighted text or images borrowed from other web sites or published material; such additions will be deleted. Contributors may use copyrighted publications as a source of information, but not as a source of sentences or phrases. Accordingly, the material may be rewritten, but only if it does not infringe on the copyright of the original or plagiarize from that source. Please see our guideline on non-free text for how to properly implement limited quotations of copyrighted text. Wikipedia takes copyright violations very seriously, and persistent violators will be blocked from editing. While we appreciate contributions, we must require all contributors to understand and comply with these policies. Thank you. --Alexrexpvt (talk) 00:53, 27 July 2009 (UTC)[reply]

Preservative

Forgive me if I've missed this information but what preservative is used in this vaccine? The NNii says that influenza vaccine is "manufactured with thimerosal as a preservative", does Zanamivir contain thimerosal? Thanks. Mimi ^(yack) 21:00, 9 August 2009 (UTC)[reply]

Zanamivir is a drug, not a vaccine. Neither zanamivir nor oseltamivir contain thimerosal. Fvasconcellos (t·c) 00:06, 10 August 2009 (UTC)[reply]

Many thanks. Mimi ^(yack) 09:15, 10 August 2009 (UTC)[reply]

Chemical synthesis

The Tamiflu entry (http://en.wikipedia.org/wiki/Tamiflu ) contains a very nice graphic showing the chemical synthesis. They further describe/discuss the problems in the production pipeline. It would be very interesting to have a similar entry for Relenza. Thanks. Jahibadkaret (talk) 11:24, 3 September 2009 (UTC)[reply]

Too Technical?

The second paragraph in "history" seems to be a bit technical for the average reader... anyone think we should maybe dum it down for the masses a bit.. -Tracer9999 (talk) 14:30, 13 October 2009 (UTC)[reply]

Something from 1918

I knew a girl
who's name was ENZA
I opened the window
and In flu enza

--77.182.164.130 (talk) 11:31, 13 May 2013 (UTC)[reply]

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