Talk:Wiskott–Aldrich syndrome

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 23 November 2020 and 20 December 2020. Further details are available on the course page. Student editor(s): CMCarlston. Peer reviewers: Afmcraig.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 13:04, 17 January 2022 (UTC)

Added

This reference was dropped in the article:

Boztug, K (2010). "Stem-cell gene therapy for the Wiskott-Aldrich syndrome". New England Journal of Medicine. 363 (20): 1918–27. doi:10.1056/NEJMoa1003548. PMID 21067383. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)</ref>

It is not a WP:MEDRS, but in this setting might be appropriate as it seems to be a success story (2 patients) of gene therapy. JFW | T@lk 12:49, 30 June 2011 (UTC)

WikiProjects Medicine

Hi! I'm a 4th year medical student at UCSF, planning to work on this entry as part of WikiProjects Medicine course in December 2020. Here are my plans for edits, and I welcome feedback/ suggestions from others:

- Change diagnosis section to table and clarify section on WAS clinical score
- Add section on recommendations for medical management, including infection prophylaxis and non-protective response to vaccinations (eg. pneumovax)
- Add section on differential diagnosis in children presenting with thrombocytopenia including ITP, Hyper-Ig syndrome, Omenn syndrome, etc.
- Add section on prognosis
- In treatment options, update to include Eltrombopag, a newly approved oral thrombopoietin receptor agonist, splenectomy for thrombocytopenia, and immunosuppression in some individuals with severe autoimmune disease
- I may also try to simplify the introduction section, and possibly some other sections (like the classification section) but am open to suggestions/ ideas of what might be helpful
- Reach out to WAS support group for additional photo, maybe showing skin findings in someone with a different skin tone <-- no replies to dates
CMCarlston (talk) 06:47, 30 November 2020 (UTC)

While I am not familiar with the article, your suggestions seem both useful and reasonable.--Quisqualis (talk) 18:27, 7 December 2020 (UTC)

Peer Review 13 Dec 2020

• Typographical
  • General: "WAS-related disorders" -- sometimes WAS is italicized, sometimes not <--Yeah, it depends on whether WAS is being used as an abbreviation for Wiskott-Aldrich syndrome or for the gene, I guess in this example it could be either
  • "The WAS-related disorders of X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN) may present similar but less severe symptoms and are caused by mutations of the same gene." -- change "similar" to "with similar" <-- Done
  • "Alleles that produce no or truncated protein have more severe effects than missense variant." -- consider "Alleles with missense variants have less severe effects than those that produce truncated proteins or no protein at all."<-- Done
  • "Although autoimmune disease and malignancy may occur in both conditions, patients with loss of WASp are at higher risk." -- remove italics around WASp, earlier you define this as the protein product and not a gene, so no italics needed <-- Done
  • "The diagnosis can made on the basis of clinical findings, the peripheral blood smear, and low immunoglobulin levels." -- "The diagnosis can be made" <-- Done
  • Table on Diagnostic Criteria - row "Definitive" - 2x usages of "WASP" whereas previously it is "WASp"<-- Done
  • "Those with higher WAS scores (e.g., 5) at younger ages (e.g., age less than 5 years old), are thought to be a highest risk for increased morbidity and mortality related to their condition." -- change to "at highest risk"<-- Done
  • "As individuals can develop more WAS-related symptoms (e.g. autoimmune disease, malignancy) with age, ones WAS score can increase over." -- last clause is unclear, change to "one's"<-- Done
  • "As WAS is primarily a disorder of the blood-forming tissues, a hematopoietic stem cell transplant, accomplished through an umbilical cord blood or bone marrow transplant offers the only current hope of cure." -- add comma after "or bone marrow transplant"<-- Done

• Organizational
  • Under Diagnosis, you say "Typically, IgM levels are low, IgA levels are elevated, and IgE levels may be elevated; paraproteins are occasionally observed." -- could reference the preceding section on signs/symptoms since Ig is more thoroughly discussed there. Also, are lab values typically included in signs/symptoms sections on wiki? Not sure.<-- This was not a part that I wrote, but I have been thinking of moving it around. Thanks for the suggestions.

• Text Content
  • Very good reading overall and covering the most important points of the disease -- no real comments here
  • Content weighted appropriately to importance -- most heavily on pathophys/genetics and diagnosis/classification, less to treatment and epi/history. <-- On my to do list though is to update the management/treatment section, and include a differential diagnosis section
  • Under Epidemiology, you could compare the incidence of this disorder to any similar rare inherited conditions. There or elsewhere, it might be useful to situate the disease in the broader context of congenital immunodeficiencies and make reference to, e.g., SCID, Ataxia-Telangiectasia, Hyper-IgM. Maybe? <-- Good suggestion. It is far more common than any of those, so something like "One of the most common hereditary immunodeficiencies at...."

• Media
  • Current images are good for the topic
  • For microthrombocytopenia, you could find an image of a normal peripheral blood smear, point out the platelets, then caption that there will be fewer and smaller platelets in WAS? Sympathize with the difficulty finding images!
  • If you feel the need to include additional images, a diagram under the Treatment section illustrating gene therapy with a lentiviral vector approach could be helpful. <-- Good idea. Maybe this or something else that would benefit from a figure in an expanded management section.

• References
  • Solid list overall. There are a few single-study references but for basic science research this seems definitely appropriate.
  • Good that there are marked "citation needed" in a few places, can work on that if time allows.

Afmcraig (talk) 22:59, 13 December 2020 (UTC)