Talk:Two-hit hypothesis

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Who formulated the hypothesis?

The following can be read in the beginning of the article: "It [the Knudsen hypothesis] was first proposed by Carl O. Nordling in 1953,[1][2] and later formulated by Alfred G. Knudson in 1971.[3]".

I read the paper by Nordling ([1]) and while it discusses the number of mutations required in the genome to develop cancer, it does not as far as I can tell at all relate to the two-hit hypothesis formulated by Knudsen which discusses that a hit (mutation) was required to each allele of the same gene (RB) to cause cancer. I would argue the statement in the Wikipedia article above quoted is false. I can however not access [2].

1. Nordling C (1953). "A new theory on cancer-inducing mechanism". Br J Cancer. 7 (1): 68–72. doi:10.1038/bjc.1953.8. PMC 2007872. PMID 13051507. Archived from the original on 20 May 2007. 2. Marte B (2006-04-01). "Milestone 9: (1953) Two-hit hypothesis - It takes (at least) two to tango". Nature Milestones Cancer. Retrieved 2007-01-22. 3. Knudson A (1971). "Mutation and cancer: statistical study of retinoblastoma". Proc Natl Acad Sci USA. 68 (4): 820–823. doi:10.1073/pnas.68.4.820. PMC 389051. PMID 5279523.

130.241.182.39 (talk) 14:15, 15 January 2019 (UTC)[reply]

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