Talk:Tumor-infiltrating lymphocytes

Contrast with tumor-associated macrophages

In contrast to TIL; tumor-associated macrophages seem to be associated with a worse outcome. Targeting the Accomplices: Homing in on Immune Cells that Aid Tumors. - Rod57 (talk) 23:22, 6 September 2011 (UTC)

Wrong content or name (since 28 May 2014)

Current name is Tumor-infiltrating lymphocytes but 90%+ of content is (since 28 May 2014) about TIL injection treatments. Perhaps we should move this content to eg. cell therapy and leave this article for details (as prior to 28 may 2014) about the TILs themselves and their diagnostic use ? - Rod57 (talk) 08:16, 30 April 2016 (UTC)

Merged old and new versions of the article. - Rod57 (talk) 09:09, 30 April 2016 (UTC)

How detect outside tumours

Are they defined by being found in tumours, or do they have characteristics that allow them to be distinguished from other lymphocytes found in say the blood ? - Rod57 (talk) 09:43, 30 April 2016 (UTC)

Despite some [loose?] talk of them being extracted from blood, Breast Cancer Immunology says "Tumor-infiltrating lymphocytes (TILs) are mononuclear immune cells that infiltrate tumor tissue and have been described in several tumor types including BC. TILs are commonly measured on histological slides after haematoxylin and eosin staining. They are located either in the stroma or within the tumor. Both stromal and intratumoral TILs are composed of different types of cells (i.e., T cells, B cells, NK cells, macrophages) in variable proportions, T cells being the most abundant cells." - Rod57 (talk) 13:29, 1 May 2016 (UTC)

May include unwanted MDSC

VISTA (protein) says TILs include myeloid-derived suppressor cells which seem to help cancers grow. - Rod57 (talk) 09:49, 28 March 2017 (UTC)