Talk:TNF inhibitor

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Possibly imprecise entry name-anti-TNF therapeutics?

By pharmacological definition, inhibitor is blocker of enzymatic activity. TNF is not an enzyme; it is a cytokine. Bioaction of TNF is blocked by affinity-based(antibody) drugs, but still, these drugs don't inhibit enzymatic action of TNF; they do sequester TNF from endogenous TNF receptor. Therefore, proper title of the entry might be "anti-TNF therapeutics". Edta450 (talk) 14:44, 13 April 2009 (UTC) Ustekinumab is not a TNF-blocker, thus it should not be listed in this chapter (psoriasis section)Vorticus (talk) 21:51, 1 May 2016 (UTC)[reply]

TNF-alpha

Could it be made clearer whether all TNF inhibitors are inhibitors of only TNF-alpha ? Rod57 (talk) 02:43, 1 December 2008 (UTC)[reply]

Pentoxyfylline

Should we mention anti-TNF activity of pentoxyfylline? JFW | T@lk 17:49, 11 December 2008 (UTC)[reply]

I've added a ref, but feel free to expand. --Arcadian (talk) 18:59, 11 December 2008 (UTC)[reply]

I think no, because many other drugs, including methotrexate, or substances may have some anti-TNF activity.Vorticus (talk) 21:52, 1 May 2016 (UTC)[reply]

Golimumab not listed?

Simponi, aka golimumab, was recently approved. [1] Ronabop (talk) 05:17, 26 April 2009 (UTC) Yes, it was approved for psoriatic arthritis. In addition to golimumab, also certolizumabVorticus (talk) 21:54, 1 May 2016 (UTC).[reply]

Side effects

It says patients are at increased risk of opportunistic fungal infections. Can anyone say why only fungal and not bacterial infections ? Are all the TNF inhibitors the same in this respect ? Are they generally immunosuppresive ? and why ? Rod57 (talk) 17:23, 23 November 2009 (UTC) A correct statement may be opportunistic infections (not only fungal). Anyway the major risk for this class of drugs is tuberculosis which is a bacterial disease.Vorticus (talk) 21:56, 1 May 2016 (UTC)[reply]

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Thalidomide is not Immunoprine

Immunoprine is Azathioprine, please correct it. The information on the article is dangerously misleading.1osecampo (talk) 21:50, 6 June 2018 (UTC)[reply]