Talk:SNAP25

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Molecular Biology: MCB

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 17 August 2020 and 2 December 2020. Further details are available on the course page. Student editor(s): BioRox333.

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Untitled

I don't know from where is this attitude for speedy deletion. The text at SySy seems very close to my entry but such texts are seen everywhere in the web. Of course that SNAP-25 binds to syntaxin and synaptobrevin - this is scientific fact and this is not copyright violation, nor plagiarism. I intend to expand this article, but I need some time to do that - I have worked on associted entries with syntaxin and synaptotagmin, so I cannot edit all at once. Danko Georgiev MD 06:14, 18 May 2006 (UTC)[reply]

I have modified the entry, so it is stub now that I intend to expand. See also the comment on my talk page. Danko Georgiev MD 06:23, 18 May 2006 (UTC)[reply]

And I have removed the speedy delete template. Squigish 06:24, 18 May 2006 (UTC)[reply]

Complexity and Context

The explanation this page gives should go from easy-to-understand to harder. Remember, Wikipedia articles should be comprehensible to a secondary school student competent in the language. The first paragraph was pretty difficult for me to work my way through, and I'm studying molecular biology in graduate school. Great job so far--the information is quite comprehensive--but please try to reorganize it a bit. See also WP:PCR. --aciel (talk) 02:52, 18 February 2008 (UTC)[reply]

SNAP = SNAP?

I am confused. Are the soluble NSF attachment proteins abbreviated SNAP the same as the synaptosome associated proteins also abbreviated SNAP? And if not which of these SNAPs is the SNAP Receptor (SNARE) able to bind? According to the ensembl database there seem to be two distinct gene families: one comprising α-, β- and γ-SNAP and the other with members called SNAP-23, SNAP-25, SNAP-29 and so on. But what is the difference? Both seem to be involved in vesicle fusion processes. This might be the reason why there is so much confusion. Even on the disambiguation page Snap SNAP-25 is used synonymically with "soluble n-ethyl maleimide senstive attachment protein". Can anybody help? —Preceding unsigned comment added by 193.175.234.39 (talk) 08:18, 16 June 2008 (UTC)[reply]

SNAP (Soluble NSF Attachment Protein) is an adaptor protein that binds both to SNAREs, on both the vesicle and plasma membrane, and NSF. The purpose of SNAP is to recruit NSF to the membrane, where it's ATPase activity is used following membrane fusion to separate the vSNARE/tSNARE complex. SNAP-25 (Synaptosome Associated Protein-25) is a type of tSNARE, a membrane protein like Syntaxin that is bound to the target membrane and interacts with vSNARES on the vesicle to initiate fusion. SNAP-23 and -29 are in this family as well I think. It is annoying that they both have the same acronym, but apparently they were both discovered and named before it was realised that they both occured in the same process. (Haagenti (talk) 23:31, 17 January 2009 (UTC))[reply]

External links modified

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