Talk:Prostaglandin E2

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 29 June 2020 and 21 August 2020. Further details are available on the course page. Student editor(s): DLPHAN, CSaeteurn, Future UCSF PharmD, SntnPhung, Cmueller6267. Peer reviewers: Y.Ma100, P. Lee UCSF, Rmondal, UCSF, C. Lin, Future UCSF Pharm.D..

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 07:19, 17 January 2022 (UTC)[reply]

older entries

I deleted: "t has recently been discovered that, injected directly into the penis, it induces a substantial erection, even for men who have become effectively impotent." since the prostaglandin used in "trimix" is prostaglandin e1 (Alprostadil). While e2 may be a vasodilator, in the absence of a confirming citation, is application to erectile dysfunction is uncertain. Tachyon 18:13, 31 January 2011 (UTC)


Unsure if this is the correct place to write this, but after reading several other articles trying to understand the ultimate cause of fever in the human body, and the corresponding reduction of it with application of NSAIDs, I came to this page (Prostaglandin E2). I think this information should be featured more prominently on the page, especially the effects of PGE2 on the hypothalamus in connection with fever and thermoregulation of the body. However I am not a specialist and also do not know if there is another page dedicated to this information already (from my brief review I did not find a good candidate). Thanks Paulsukhanov (talk) 16:40, 13 April 2014 (UTC)Paul[reply]

TB disease modulator

Maybe this is jumping the gun but PGE2 looks promising as a treatment for tuberculosis. "Details subsequently emerged of how IL-1 normally promotes the synthesis of PGE2 by COX2, enabling macrophages to restrict M. tuberculosis growth during infection. ... PGE2 synthesis also increased alongside levels of IL-1 in the absence of type I interferon (IFN) signalling ... increasing PGE2 levels by clinically approved means enhanced the survival of M. tuberculosis-infected mice. These data ultimately provide the proof of concept that tipping the eicosanoid balance in favour of PGE2 constitutes an effective strategy against TB." [1] YakbutterT (talk) 19:16, 19 September 2014 (UTC)[reply]

References

  1. ^ Mayer-Barber, K. D. et al. Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature 511, 99–103 (2014)

Foundations II 2020 Group 22 proposed edits

Our groups plans to edit this article to include more citations, add more to the sections of history, society and culture, more on the mechanism of action, and physiological side effects. We plan to reorganize the information to make it easier to read. CSaeteurn, Future UCSF PharmD (talk) 20:43, 28 July 2020 (UTC)[reply]

Should information about PGE2 natural synthesis be included within the Wiki? Sntnphung 11:10, 30 July 2020 (UTC)

@CSaeteurn, Future UCSF PharmD: ; Cc: SntnPhung, KTruong1337
Please be careful with citation name conflicts. You may see a message like this in the References section. You can check the article preview before saving after editing the full article or in the saved article after editing a section.
Cite error: The named reference ":3" was defined multiple times with different content (see the help page).
You can click here to see the diff that introduced the conflict
Here are the conflicting citations. They are in different sections. I recommend using meaningful citation names instead of :1, :2, :3, etc.
<ref name=":3">{{Cite journal|last=Tenore|first=Josie L.|date=2003-05-15|title=Methods for cervical ripening and induction of labor|url=https://www.ncbi.nlm.nih.gov/pubmed/12776961|journal=American Family Physician|volume=67|issue=10|pages=2123–2128|issn=0002-838X|pmid=12776961}} :
<ref name=":3">{{Citation|last=Xi|first=Michael|title=Prostaglandin E2 (Dinoprostone)|date=2020|url=http://www.ncbi.nlm.nih.gov/books/NBK545279/|work=StatPearls|volume=|pages=|place=Treasure Island (FL)|publisher=StatPearls Publishing|pmid=31424863|last2=Gerriets|first2=Valerie}} :
--Whywhenwhohow (talk) 02:41, 3 August 2020 (UTC)[reply]

Foundations II 2020 Peer Review Edits

Do the group’s edits improve the article as described in the Wikipedia peer review “Guiding framework”? Yes, this group has made edits that improve the article. They added more citations as a part of their goal, however, certain parts of the paragraph are cited from the same source after every single sentence. This needs to be condensed and represented one time after the entire paragraph if it is from the same citation. --Rmondal, UCSF (talk) 20:56, 3 August 2020 (UTC)https://en.wikipedia.org/w/index.php?title=Talk:Prostaglandin_E2&action=edit&section=4[reply]

Has the group achieved its overall goals for improvement? Yes, the group has reached their overall goals of adding more citations, including more information on sections, and reorganizing the structure so it is easier to read. --Rmondal, UCSF (talk) 20:56, 3 August 2020 (UTC)[reply]

Does the draft submission reflect a neutral point of view? If not, specify… Yes, for the most part. The repeated use of the word "patient" could make this article seem professional-specific. (C. Lin, Future UCSF Pharm.D. (talk) 20:48, 3 August 2020 (UTC))[reply]

Are the points included verifiable with cited secondary sources that are freely available? If not, specify… Most sources are secondary except one. Citation #36 (PMID:26734422) seems a primary source to me. Most sources are freely available online except a few, citation #23 (PMID: 21116297), #26(PMID:24768319), #28 (PMID: 19623003), #29 (PMID: 4599109), #30 (PMID: 6391777), #42 (PMID: 10368503), #43 (PMID: 15511754), #44. There are also some duplicate citations. Citations #34, #40 and #41 are the same article (PMID: 31424863). Citations #10, 17, 20, 22 directed me to the same chapter (Chapter 18 in Basic & Clinical Pharmacology). (Y.Ma100 (talk) 21:47, 3 August 2020 (UTC))[reply]

Are the edits formatted consistent with Wikipedia’s manual of style? If not, specify… The group has made clear sections breaking down the topics and easier to read. However, the language used needs to be more in lay language for the common reader such as the styles of other Wikipedia articles. The word "patient" is used a lot as well which assumes the audience as an associate of the healthcare field. The structure overall is nice with no bullet lists and paragraph formatting and titles are appropriate. --Rmondal, UCSF (talk) 21:00, 3 August 2020 (UTC)--Rmondal, UCSF (talk) 21:00, 3 August 2020 (UTC)[reply]

Is there any evidence of plagiarism or copyright violation? If yes, specify… No, there is no evidence of plagiarism or copyright (P. Lee UCSF (talk) 21:00, 3 August 2020 (UTC))[reply]

The first sentence for contraindication for the cervical gel is long. I think it would be easier to read if you broke up the sentence (P. Lee UCSF (talk) 21:14, 3 August 2020 (UTC))[reply]

WikiProject Medicine

To @DLPHAN:, @SntnPhung:, @Cmueller6267: @CSaeteurn, Future UCSF PharmD: As a member of WP:WikiProject Medicine I have volunteered to watch this article while it is a Wikipedia:Wiki Ed/UCSF/Foundations II (Summer 2020) assignment. I will be creating comments here at Talk. Feel free to ask me questions in those sections or on my Talk page. David notMD (talk) 10:51, 14 August 2020 (UTC)[reply]

Acronym, also, PGE2 or PGE2?

There is no need to establish the PGE2 acronym over and over and over again! Also the article needs to be consistent throughout for the "2" in the acronym being subscripted or not. David notMD (talk) 10:24, 14 August 2020 (UTC)[reply]

Too much "How to"

Wikipedia is not supposed to be "How to". The entire Administration section should be reconsidered. David notMD (talk) 10:33, 14 August 2020 (UTC)[reply]

Society and culture

This entire section should be deleted. "Society and culture" refers to how the topic of an article is mentioned/discussed/referred to outside its field. So, not information on brand names. See Birth control#Society and culture for an example. David notMD (talk) 10:38, 14 August 2020 (UTC)[reply]

Students did not return to article, so I went ahead and deleted it. David notMD (talk) 10:07, 21 August 2020 (UTC)[reply]

Physiological effects section

This should be limited to the functions of endogenous PGE2. Some drug content has been added. Also, if endogenous is covered in the article before medicinal, then the paragraphs in the Lead should be reordered. David notMD (talk) 10:42, 14 August 2020 (UTC)[reply]

People or person, not "patient"

As already mentioned in the reviewers comments, Wikipedia prefers to not use "patient." David notMD (talk) 11:01, 14 August 2020 (UTC)[reply]

References

First, kudos for refs being in a proper format. Wikipedia has a guideline on what are considered reliable sources for references for medical topics at WP:MEDRS. This includes not using in vitro or animal lit, or individual clinical trials. I believe that refs 23, 25, 31, 32 and 36 do not quality. Older refs should be replaced with newer if possible (#37). And #38 is just wrong (AGOC about caffeine). David notMD (talk) 11:10, 14 August 2020 (UTC)[reply]

Text and non-MEDRS refs deleted. David notMD (talk) 15:46, 26 August 2020 (UTC)[reply]
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