Talk:Processivity
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Doesn't processivity have to do with ANY enzyme's kinetic speed, not just the enzymes involved in DNA copying?
processivity for motor proteins
Can anyone explain what processivity exactly means for motor proteins? Ygramul (talk) 23:59, 17 April 2008 (UTC)
Processivity is NOT just related to DNA polymerases, it has to do with any enzyme that acts on a polymer - myosin, for example. In motor proteins, processivity means the ability of the protein to continue moving along the cytoskeleton without dissociating from it completely. This does NOT relate to rxn rate (kinetics) at all, a highly processive enzyme can still be very slow.—Preceding unsigned comment added by 152.3.152.18 (talk) 14:40, 12 November 2008 (UTC)
Someone needs to expand this article to contain a generalized definition and explanation of processivity. This must have been written by someone with very specific experience with polymerases, and less with motor proteins and other processive processes.Ryanfrei (talk) 15:32, 3 June 2009 (UTC)
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Rate-limiting step in polymerase reactions is NOT template binding
The statement in this article that the rate-limiting step in the DNA polymerase reaction is binding to the template is incorrect. The lack of a reference citation for this statement is therefore unsurprising. Recent work has shown that the rate-limiting step for DNA synthesis by DNA polymerase occurs after nucleotide addition and can thus only take place after template binding, The slow step in the reaction has been tentatively identified as the finger-opening conformational change that is required for DNA release from the enzyme. See https://doi.org/10.1016/j.jmb.2021.167410 for a recent reference that explains this. 104.59.220.241 (talk) 00:09, 31 January 2024 (UTC)