Talk:MAPEG family

what makes them a 'family'

if their function is divergent, why are they grouped together? Just because they're 'transmembrane proteins?' --Ryan Wise (talk) 19:17, 12 April 2008 (UTC)

@ Ryan Wise: They are grouped together because of their high degree of identity on the gene and the protein level (up to 42% identity, similarity is even higher). This makes the evolutionary related. In fact, MPGES1, MGST2 and MGST3 were identified by database searches to match FLAP and LTC4S. Functionally, this superfamily can be divided into two groups, the first of which (MPGES1, FLAP and LTC4S) comprises proteins involved in the endogenous metabolism of physiologically important reactive oxygenated lipid mediators, while the second group (MGST1, MGST2 and MGST3) comprises proteins that are involved in detoxification of highly reactive lipophilic compounds of both exogenous and endogenous origin. (Jakobsson PJ Protein Science, 8, 689, 1999)

general comment: the protein structure shown (lithostathine) has nothing to do with the MAPEG family. Please check

• Jegerschöld, C., Pawelzik, S.-C., Purhonen, P., Bhakat, P., Gheorghe, K. R., Gyobu, N., Mitsuoka, K., Morgenstern, R., Jakobsson, P.-J., and Hebert, H. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 11110-11115

• Holm, P. J., Bhakat, P., Jegerschöld, C., Gyobu, N., Mitsuoka, K., Fujiyoshi, Y., Morgenstern, R., and Hebert, H. (2006) J. Mol. Biol. 360, 934-945

• Martinez Molina, D., Wetterholm, A., Kohl, A., McCarthy, A. A., Niegowski, D., Ohlson, E., Hammarberg, T., Eshaghi, S., Haeggström, J. Z., and Nordlund, P. (2007) Nature 448, 613-616

• Ago, H., Kanaoka, Y., Irikura, D., Lam, B. K., Shimamura, T., Austen, K. F., and Miyano, M. (2007) Nature 448, 609-612

and

• Ferguson, A. D., McKeever, B. M., Xu, S., Wisniewski, D., Miller, D. K., Yamin, T.-T., Spencer, R. H., Chu, L., Ujjainwalla, F., Cunningham, B. R., Evans, J. F., and Becker, J. W. (2007) Science 317, 510-512 —Preceding unsigned comment added by 213.100.136.234 (talk) 20:14, 26 September 2010 (UTC)