Talk:Lobular carcinoma in situ

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Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Hl533. Peer reviewers: D7ng77.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 02:46, 17 January 2022 (UTC)[reply]

Wikiproject Medicine Student Workplan

Greetings Wikipedia community. I am a 4th year medical student enrolled in a Wikiproject course and have been tasked with enhancing a Wikipedia page about a medical topic. I am personally interested in the fields of Anatomic and Clinical Pathology - and would like to help develop this page about Lobular Carcinoma In-Situ. Neoplasia involving the TDLU has been and continues to be closely studied in the Pathology community given the progressive nature of invasive carcinoma from histologically identifiable precursor lesions, updates in nomenclature, and controversial management guidelines. The current article has been graded as a “Start” article due to lack of references and detail; my aim is to enrich the current page with more information about LCIS from high quality reviews and medical databases. I have developed a workplan by section:

Classification: I would like to expand the opening paragraph with a brief introduction to the TLDU of the breast, explain how LCIS is part of a spectrum of change that evidences a linear progression to invasive carcinoma, and make understandable to readers how it is a microscopic diagnosis, based heavily on cellular characteristics seen on histologic slides and through immunohistochemical testing.

History: I will build off the classification section, which will provide an overview of the entity, and offer some historic milestones in the discovery of LCIS, and which original descriptions still hold true in current literature.

Epidemiology: I would like to add this section to provide details about rates of incidental discovery, comparison to rates of diagnosis to the LCIS parallel, DCIS, and updates information on risk of development or coincidental finding alongside invasive carcinoma.

Causes: (Genetics) I aim to provide more specific details about the most recent updates to genetic alterations seen in LCIS and perhaps their relation to those of precursor lesions and further progression to invasive carcinoma. I would also like to augment the genetic discussion with pertinent pathophysiologic information to give readers a sense of mechanism.

Diagnosis: (Morphology) I aim to better develop this section as a general “Histopathology” section. I would like to describe in more detail the morphologic traits of LCIS cells and further expand the section to include architectural descriptions of the tissue as well as mammographic findings that may have led clinicians to perform a biopsy in the first place. Furthermore, I would like to introduce the morphological subclasses of LCIS due to their implications on prognosis (to be discussed in later section). In addition, I hope to provide a brief comparison to the tissue architecture and cell morphology seen in precursor lesions.

Signs and Symptoms: (Clinical Features) I hope to add a new section on clinical implications of LCIS found microscopically. Tentatively, this may include data about signs on physical exam, indications for mammography, and associated correlations on gross specimen examination.

Treatment: I aim to expand on management options, viewpoints, and areas of controversy in this section. The information presented is well cited and accurately presented; I would simply like to reference some more updated reviews and texts as well as touch on the finer details of different management strategies.

Prognosis: I aim to provide more detailed rates of occurrence, progression to invasive lobular, and response to treatment based on secondary sources. I would also like to tie in correlation with development of other malignancies such as DCIS, which have been well cited in the literature, and revisit the importance of the different morphological subclasses mentioned in the morphology/histopathology section.

In summary, I would like to expand on the foundation of knowledge that comprises the article currently with more specific details that are well sourced from secondary scientific sources and established texts. I would greatly appreciate any feedback, assistance, or references Wikipedia members viewing this page may offer and welcome anyone passionate about Pathology or Histology who would like to get involved.

Sources Used: 1[1] 2[2] 3[3] 4[4] 5[5] 6[6] 7[7]


Peer Review
- Overall great article, you met all of your goals as stated above. Here are a few suggestions I have for making this article better.
- Change the headings from all capital letters to proper capitalization.
- It may be beneficial to add links to "Lobular neoplasia", "Atypical Lobular Hyperplasia", "Invasive Lobular Carcinoma", "Ductal Carcinoma in situ"
- Under "Classification" there is a citation [8] that is not connected with anything.
- Under "Classification", check the grammar of the first paragraph.
- There is some overlap in information between the "Classification" and "History" sections, maybe consider deleting the overlapping information from one of them.
- Under "Treatment" there is a citation [17] that is not connected with anything.
D7ng77 (talk) 15:23, 24 March 2018 (UTC)[reply]

References

  1. ^ Wen, Hannah Y. (1 March 2018). "Lobular Carcinoma In Situ". Surgical Pathology Clinics. 11 (1).
  2. ^ King, Tari A. (1 July 2014). "Lobular Neoplasia". Surgical Oncology Clinics of North America. 23 (3).
  3. ^ Collins, Laura C. (1 March 2018). "Precursor Lesions of the Low Grade Breast Neoplasia Pathway". Surgical Pathology Clinics. 11 (1).
  4. ^ Logan, Greg J.; Dabbs, David J.; Lucas, Peter C.; Jankowitz, Rachel C.; Brown, Daniel D.; Clark, Beth Z.; Oesterreich, Steffi; McAuliffe, Priscilla F. (4 June 2015). "Molecular drivers of lobular carcinoma in situ". Breast Cancer Research. 17 (1). doi:10.1186/s13058-015-0580-5.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  5. ^ Pieri, Andrew (2014). "Pleomorphic lobular carcinoma in situ of the breast: Can the evidence guide practice?". World Journal of Clinical Oncology. 5 (3): 546. doi:10.5306/wjco.v5.i3.546.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Jorns, Julie; Sabel, Michael S.; Pang, Judy C. (October 2014). "Lobular Neoplasia: Morphology and Management". Archives of Pathology & Laboratory Medicine. 138 (10): 1344–1349. doi:10.5858/arpa.2014-0278-CC.
  7. ^ Canas-Marques, Rita; Schnitt, Stuart J (January 2016). "E-cadherin immunohistochemistry in breast pathology: uses and pitfalls". Histopathology. 68 (1): 57–69. doi:10.1111/his.12869.

Wikiproject Medicine Student Draft 1 Completion

Hello again,

As of 3/23/2018, I would like to update any viewers and editors to my changes to this LCIS article. I have completed edits based on my original workplan posted above and reviewed all citations. I am currently searching viable image databases for appropriate pictures to demonstrate morphology and tissue architecture. Please, let me know if you have any suggestions or comments.

Much appreciated, Wikiprojects Medicine Student — Preceding unsigned comment added by Hl533 (talk • contribs) 19:53, 23 March 2018 (UTC)[reply]

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