Talk:List of medicine contamination incidents

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2012-2019 Contamination of Angiotensin II Inhibitor ("Sartan") Medications with N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA)

Beginning in 2012, the process for making tetrazole, a chemical intermediate in the production of various angiotensin II inhibitor medications for hypertension (popularly known by their common drug name suffix "sartan") was changed by generic drug manufacturers in favor of several cheaper and more efficient processes. These processes caused tetrazole to be contaminated with N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) which cause genetic damage and cancer according to a report by German researcher Professor Dr. Fritz Sörgel.

This contamination was not detected until 2018. In the intervening years massive amounts of generic versions of angiotensin II inhibitor ("Sartan") blood pressure medications were made with contaminated tetrazole. Patients receiving these drugs were exposed to genotoxic and carcinogenic N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) from 2012 until the drugs were recalled from the world drug market in 2018. The incident, according to a column by medicinal chemist and pharmaceutical industry blogger Dr. Derek Lowe, points to a greater problem. Generic drug manufacturers often change the way in which prescriptiion drug ingredients are made in order to save costs of making them. So this kind of contamination incident may not be isolated.

I'm throwing this out there hoping for some discussion before I change our article to include this rather large, extensive, alarming and notable contamination incident. --loupgarous (talk) 00:56, 17 April 2020 (UTC)[reply]

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