Talk:Lipoxin

Untitled

I'm removing the redirect (from Lipoxin to Eicosanoid) because Lipoxins are sometimes considered to be a subclass of eicosanoid, but they're different. And I have a Lipoxin stub ready. And the Eicosanoid page doesn't even mention lipoxins. David.Throop 06:31, 8 February 2006 (UTC)

How are lipoxins different from other eicosanoids? They are very similar to leukotriene B4, diHETEs (in general) and resolvin E1, for example. GregKeyes 01:13, 19 March 2006 (UTC)

As it says on the eicosanoid page "Current usage limits this (the term 'eicosanoid') to the leukotrienes and prostanoids, but several other classes are technically eicosanoid, including the resolvins, isofurans, isoprostanes, lipoxins, epoxyeicosatrienoic acids (EETs), neuroprotectin D and some endocannabinoids."

All these classes were discovered later than the thromboxanes and prostanoids. I can't explain why they aren't included in the eicosanoids. Some writers do include some of them with the eicosanoids. I'll just note that most of the current literature on them uses such terms as eicosanoid-like. David.Throop 13:25, 19 March 2006 (UTC)

Assessment comment

The comment(s) below were originally left at Talk:Lipoxin/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

To Do: Who did the first complete synthesis? Have other LX been spotted, after LXA and LXB? What enzymes convert AA to LX? What receptors for LX have been identified? Are there other agonist/antagonist for the lipoxin receptor(s)? What tissues generate LX? Is LX itself a reactive species? Is LX transported after it is created? How is LX deactivated? Spontaneously or enzymatically? Does LX act within the cell, or within the nucleus, or in the extracellular space? Do LX compete with the resolvins and epi-lipoxins, or act in concert with them? Do they share the same receptors? Have any medical disorders been pinned to dis-regulation of LX? Are LX analogues used as medicines? experimental tools? Do dietary levels of EFAs affect lipoxin levels? Have LX or LX-analogues been generated from DGLA? Mead acid? The endo-cannabinoids? David.Throop 15:54, 6 November 2007 (UTC)

Last edited at 15:54, 6 November 2007 (UTC). Substituted at 22:05, 29 April 2016 (UTC)