Talk:Li–Fraumeni syndrome

From WikiProjectMed
Jump to navigation Jump to search

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Arm7wb, Mmcfz5, Jwhd58, Sumidhak, Biermannjordan, Clw45f, Artxw9.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 02:46, 17 January 2022 (UTC)[reply]

PET scans

18FDG-PET may be a useful way of finding the cancers before they cause trouble: http://jama.ama-assn.org/cgi/content/abstract/299/11/1315?etoc JFW | T@lk 15:32, 18 March 2008 (UTC)[reply]

Symptoms

What are the symptoms?

The DarkArcher was here (talk) 04:48, 11 July 2008 (UTC)[reply]

Updating and Adding Information

Hello, I am a undergraduate student in Wisconsin and am working on a project for an English class. I have recently done a large project on Li-Fraumeni syndrome, and was looking to add some information to this article, and update existing information that is not 100% accurate. As of now, I am looking to add information to the pathology section. I am not really sure what the LFS1 and LFS2 is about so I might change that(possible use the gene affected as the heading instead). I was also looking to add some information about LFS-like individuals, who do not have any detectable mutations, but display the LFS phenotype. Also I would possibly like to add some theorized reasons (CNVS, etc.) for the variations in phenotypes (different cancer types, age of onset, etc.). I am very new to Wikipedia editing so any help and or ideas about would to write about would be greatly appreciated.


Mscott11 (talk) 21:08, 9 December 2014 (UTC)[reply]

Does all relevant information have the proper citations included?LyndzieB (talk) 19:51, 3 November 2016 (UTC)[reply]

Diagnosis

There is very little information on the diagnosis of this disease. Specifically, how can predisposition factors be diagnosed before the cancer is diagnosed?Mmh3k5 (talk) 02:49, 8 November 2016 (UTC)[reply]

Are there multiple types of mutations that causes the disease, and how do they affect the protein in relation to phenotype? Clw45f (talk) 23:55, 9 November 2016 (UTC)[reply]

Is there currently genetic testing available for this disease? If so how accessible is the testing? Clw45f (talk) 23:57, 9 November 2016 (UTC)[reply]

Treatment

Are there any valuable treatment options for individuals with this disease? Arm7wb (talk) 19:56, 3 November 2016 (UTC)[reply]


Are there any gene therapy trials that have been done? — Preceding unsigned comment added by Artxw9 (talkcontribs) 15:33, 7 November 2016 (UTC)[reply]

Characteristics

What are some other major characteristics of Li-Fraumeni syndrome and are there any major phenotypes associated with this disease? Arm7wb (talk) 21:26, 3 November 2016 (UTC)[reply]

What is the genotype-phenotype correlation for LFS if any? Mes455 (talk) 01:46, 7 November 2016 (UTC)mes455[reply]

What are the molecular mechanisms for malignancy as a result of LFS genetic mutations? Mes455 (talk) 01:46, 7 November 2016 (UTC)mes455[reply]

Symptoms

What are the symptoms associated specifically with this disease?LyndzieB (talk) 19:58, 3 November 2016 (UTC)[reply]

Epidemiology

This section needs a lot of work, seems to be all over the place. I also think that we should clarify what an epidemiological approach is — Preceding unsigned comment added by Artxw9 (talkcontribs) 15:30, 7 November 2016 (UTC)[reply]

What is the prevalence of the disease? It's a little confusing how the article says it's rare and then follows that up with more than 500 families have the trait.

Pathology

What are the Birch and Eeles criteria? — Preceding unsigned comment added by Artxw9 (talkcontribs) 15:34, 7 November 2016 (UTC)[reply]

Review

doi:10.1111/bjh.14461 JFW | T@lk 16:08, 22 February 2017 (UTC)[reply]

Li-Fraumeni

My wife died from cancer. She had breast cancer but ultimately had a soft tissue sarcoma. She was diagnosed with Li-Fraumeni syndrome. She participated with professor David Johnson at Vanderbilt University Medical School by being interviewed on stage in front of the medical students. My hope is Dr Jennifer Doudna at Cal Berkley will continue her CRISPR research and find a cure for the p53 genetic mutation. Thanks to her there’s hope for my children, one that has recently been diagnosed with breast cancer and tested positive for the p53 mutation. 152.86.90.145 (talk) 19:39, 17 November 2021 (UTC)[reply]