Talk:Leydig cell tumour
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about Leydig tumour cell line
English is not my mother tongue, so there will be some unclear grammar. But I think "In the late 20th century, a variety of Leydig cancer cell lines were developed to study the function of leydig." is consistent with source "Leydig cells: formation, function, and regulation" the section "Groundbreaking early findings" paragraph 3：
The development in 1981 by Mario Ascoli of the hormone-dependent steroid producing mouse tumor Leydig cell line, MA-10, was an important step that, over the years, has allowed the undertaking of numerous studies designed to understand the mechanism regulating Leydig cell steroidogenesis [37]. However, MA-10 cells do not express CYP17A1, and thus the major steroid product made is progesterone. Attempts to generate androgen-producing Leydig cell lines have been met with limited success. In 1968, Sato and colleagues developed the R2C rat tumor Leydig cell line that produced progesterone in a constitutive, hormone-independent, manner [38]. In 1980, Mather developed the TM3 mouse cell line believed to be derived from immature Leydig cells [39]. Although these cells produced testosterone, there was only limited if any response to LH. In 1982, Rebois established the MLTC-1 mouse Leydig tumor cell line [40]. These cells are similar to MA-10 cells in that they were generated from the same tumor as MA-10 cells and the main steroid product is progesterone. In 1987, Finaz and colleagues developed the K9 Leydig cell line, cells that were able to produce testosterone in response to hormone treatment and had characteristics of normal Leydig cells [41]. In 2012, the BLTK-1 Leydig cell line was developed from a testicular tumor [42]. These cells retain functional LHCGR-mediated steroidogenesis, producing progesterone, testosterone, and estradiol.
In my initial plan, I intended to create a table as follows：
| name | year developed | principal produce | hormone response | species | ref |
|---|---|---|---|---|---|
| MA-10 | 1981 | progesterone | LH-dependent | mouse | [37] |
| R2C | 1968 | progesterone | LH-independent | rat | [38] |
| TM3 | 1980 | testosterone | LH-independent | mouse | [39] |
| MLTC-1 | 1982 | progesterone | LH-dependent | mouse | [40] |
| K9 | 1987 | testosterone | LH-dependent | mouse | [41] |
| BLTK-1 | 2012 | progesterone, testosterone, and estradiol | LH-dependent | mouse | [42] |
But I think these contents are too detailed. The most famous tumour cell line HeLa has no it's own paragragh in Cervical cancer. So maybe these technical of cell biology research not deserving of its own section.--Htmlzycq (talk) 02:19, 1 October 2019 (UTC)
- Maybe this list can organize like this page ——List of breast cancer cell lines? --Htmlzycq (talk) 11:00, 6 October 2019 (UTC)
- {{reply to|Htmlzycq]] I'll copy this discussion to the talk page of the Leydig cell tumor article. We can discuss there. Michelangelo1992 (talk) 22:19, 6 October 2019 (UTC)
- I have copied this from my personal page in case other interested editors would like to weigh in. Personally I am not sure what value such a table would add to the article, but perhaps there is something that I am not seeing. Can you explain what information you are trying to convey and why it would lead to a better understanding of Leydig Cell Tumors? Also, I think such information, if included, could be best incorporated into a "research" or "pathophysiology" section rather than its own section. Thanks for your contributions. Michelangelo1992 (talk) 22:22, 6 October 2019 (UTC)
@Michelangelo1992: Thank you. The article Prostate cancer, a former featured article. The information of cancer cell lines, such as PC3/LNCaP, in subsection "Cancer models" of section "research". Maybe these two paragraph can organize to a list as the figure right like the the corresponding list of breast cancer.--Htmlzycq (talk) 05:37, 8 October 2019 (UTC)
I'm a researcher, not a doctor, so all I know is that this information is important for the study of Leydig cell itselve. Maybe after a professional in this field has extended the page to article Prostate cancer's level, it's appropriate to put this information on the page.--Htmlzycq (talk) 08:04, 8 October 2019 (UTC)