Talk:Juxtaglomerular apparatus

Why all this talk about NaCl?

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Seeing as we are dealing with an aqueous medium, wouldn't it be more appropriate to focus simply on sodium ions. My understanding is that chlorine, as with other mono- and di- valent ions are secondary to sodium ions in terms of importance in nephrogenic regulatory mechanisms. —Preceding unsigned comment added by 99.255.162.25 (talk) 19:53, 26 April 2009 (UTC)

I'm not sure I understand the query - it is true that sodium is by far the most important ion in terms of fluid balancing and regulatory mechanisms, but chloride being the main extracellular anion it seems common to think of them together. In this case, as Alberto.fabrizio mentions the first co-transporter is NaCl. I am unsure as to whether inside the cells it is the change in sodium or chloride concentrations that effects the response. Perhaps some reading is needed. |→ Spaully^₪† 23:54, 18 June 2009 (GMT)

You're right, but I think chloride is needed by the first cotrasporter. So since the proportion of Sodium and Chloride is 1:1 in the working trasporter, speakin of NaCl looks like a semplification even though it's an imprecision.

Moreover, found here ( http://barttersite.org/what-is-gitelmans-syndrome/#more-175 ) something about magnesium. Anyone knows more?

note: md cells doesnt reabsorb sodium with na-cl cotransporter. they absorb it via na K 2cl cotransporter. thats why loop diuretics like furosemid promote prostoglandin synthesis — Preceding unsigned comment added by 78.169.182.51 (talk) 10:13, 26 June 2011 (UTC)

Alberti.fabrizio (talk) 23:15, 18 June 2009 (UTC)Alberti.fabrizio

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

3 types of cells, unclear

'There are 3 different types of cells in the Juxtaglomerular Apparatus: distal convoluted tubule, afferent arteriole and juxtaglomerular cells.' This is confusing and only two types of cells are discussed following this statement, with little or no connection to this initial statement. CrocodilesAreForWimps (talk) 04:20, 31 July 2012 (UTC)