Talk:Inactivated vaccine

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Untitled

This article should be identified as a stub. Very little information about the mechanism of inactivated vaccines is given, such as the ability to produce antibodies, which kind of antibodies it produces, how that affects the immune response, ect.

A brief comparison with live vaccines would be useful.

The article states that inactivated vaccines are viral proteins, but then proceeds to list both viral and bacterial pathogens. Are there inactivated vaccines for bacteria? If so, the introductions should reflect this. Druep (talk) 23:15, 2 January 2011 (UTC)[reply]

The lead section is currently more detailed than the mechanism section. I intend to expand on the mechanism section and potentially move some mechanism information to its proper section. I hope to add a section for "advantages/disadvantages" or for "efficacy" and include a comparison to live attenuated vaccines. I also intend to add a contents box.MrBugsyBubz (talk) 16:57, 7 November 2021 (UTC)[reply]

Peer Review of article (as it exists on Nov. 17, 2021)

Lead: Solid lead section with a concise yet broad explanation of the topic and major sections to be covered.
Content: Great work reorganizing prior work into more sensible structure and expanding sections to include "Types" and "Advantages and Disadvantages".
Tone and Balance: Neutral article that did not take a pro-vaccine stance rather presented facts in a logical, well-organized way.
Sources and references: Added references from many good quality research articles and other quality sources. Sources referenced were mostly very up-to-date/recent articles.
Organization: Great job moving content around from original disorganized lead article to make it well thought out and sensible.
Images and media: I appreciated the image of soldiers receiving typhoid vaccine in the infobox. Consider adding other relevant info to the infobox.
Overall: Strong work! This article has gained significant improvements through your contributions for the benefit of many, many people that will view the page into the future. In my opinion, this has gone from a start class to C class article. My only suggestion is to consider adding to the infobox.

Gasdoc1991 (talk) 20:27, 17 November 2021 (UTC)[reply]

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 25 October 2021 and 20 November 2021. Further details are available on the course page. Student editor(s): MrBugsyBubz. Peer reviewers: Gasdoc1991.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 00:22, 17 January 2022 (UTC)[reply]

Inactivated vaccine meaning "whole-organism killed vaccine" vs "non-live vaccine"

Depending on the sources used, the term "inactivated vaccine" can refer to "non-live vaccines" (killed antigen, subunit, toxoid, etc) or to "killed whole-organism vaccines" specifically. This difference in meaning was even present in prominent reliable organizations (see the CDC^[1] vs WHO^[2] reference added to article). WHO even uses the term differently among their own material (See WHO's information on vaccine types^[2] and their information on inactivated influenza vaccine types^[3]).

I addressed this very briefly in the "Types" section but it should probably be addressed with more clarity in this article (and related articles like subunit vaccine). I wasn't entirely sure the best way to approach this but did try to be clear when comparing types of inactivated vaccines within the "Advantages and disadvantages" section. It seems the "Examples" section refers to vaccines that are (or have an option for) specifically killed whole-organism vaccine. If so, it may help to make that clear.

MrBugsyBubz (talk) 15:28, 21 November 2021 (UTC)[reply]

My (limited) impression is that most cases of the phrase refers to "killed". That's also what how the lede understands it. Artoria 2e5 🌉 04:54, 17 October 2023 (UTC)[reply]

References

^ Wodi AP, Morelli V (2021). "Chapter 1: Principles of Vaccination" (PDF). In Hall E, Wodi AP, Hamborsky J, Morelli V, Schilllie S (eds.). Epidemiology and Prevention of Vaccine-Preventable Diseases (14th ed.). Washington, D.C.: Public Health Foundation, Centers for Disease Control and Prevention.
^ ^a ^b "Types of vaccines - WHO Vaccine Safety Basics". vaccine-safety-training.org. World Health Organization (WHO). Retrieved 2021-11-15.{{cite web}}: CS1 maint: url-status (link)
^ WHO Expert Committee on Biological Standardization (19 June 2019). "Influenza". World Health Organization (WHO). Retrieved 22 October 2021.

Ofvmatter

Of.matter 89.176.121.31 (talk) 23:46, 30 January 2023 (UTC)[reply]

Contradiction?

In section "Types", this article states, "Inactivated vaccines often refer to non-live vaccines. They are further classified depending on the method used to inactivate the pathogen:" and then lists four types, one of which is "Subunit vaccines".

However, article subunit vaccine begins, "A subunit vaccine is a vaccine that contains purified parts of the pathogen that are antigenic, or necessary to elicit a protective immune response. A "subunit" vaccine doesn't contain the whole pathogen, unlike live attenuated or inactivated vaccine, . . .".

This seems to be a contradiction. Either a subunit vaccine is a type of inactivated vaccine, or it is not and shouldn't be listed as a type of inactivated vaccine.Hedles (talk) 14:29, 21 March 2023 (UTC)[reply]

[CDCPinkBook2021Ch1-1] Wodi AP, Morelli V (2021). "Chapter 1: Principles of Vaccination" (PDF). In Hall E, Wodi AP, Hamborsky J, Morelli V, Schilllie S (eds.). Epidemiology and Prevention of Vaccine-Preventable Diseases (14th ed.). Washington, D.C.: Public Health Foundation, Centers for Disease Control and Prevention.

[WHOVSB_Types-2] "Types of vaccines - WHO Vaccine Safety Basics". vaccine-safety-training.org. World Health Organization (WHO). Retrieved 2021-11-15.{{cite web}}: CS1 maint: url-status (link)

[WHOinfluenza-3] WHO Expert Committee on Biological Standardization (19 June 2019). "Influenza". World Health Organization (WHO). Retrieved 22 October 2021.

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