Talk:IDH1

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Hi, I was thinking of doing a small edit to this page to add information regarding the IDH1 mutation in cancer and it’s implications. This is my first edit to a wikipedia page so if there is anything I should change please let me know.

IDH1 mutations are heterozygous, typically involving a single amino acid substitution in the active site of the enzyme in codon 132.^[1] The mutation results in a loss of normal enzymatic function and the abnormal production of 2-hydroxyglutarate (2-HG). 2-HG has been found to inhibit enzymatic function of many alpha-ketoglutarate dependent dioxygenases, including histone demethylases, causing widespread changes in histone methylation.

Thanks,

Mbanting (talk) 15:38, 20 September 2015 (UTC)[reply]

^ Das, Sunit; Karamchandani, Jason (October 2014). "IDH Mutation in Glioma". JAMA Neurology. 71 (10): 1319-1325. {{cite journal}}: |access-date= requires |url= (help)

Hi, I will be editing this page for AdGen 3595 at the University of Western Ontario and I will be adding information about mutations in "IDH1", the implications and the clinical relevance of these mutations, as well as some accepted research findings based on review articles.

Review papers I will use:

Liu X & Ling ZQ (2015). Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors. Histology Histopathology 30, 1155-1160.

Dimitrov L, Hong C, Yang C, Zhuang Z & Heiss J (2015). New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma. International Journal of Medical Sciences 12, 201-213.

Horbinski C (2013). What do we know about IDH1/2 mutations so far, and how do we use it?. Acta Neuropathologica 125, 621-636.

Huse J & Aldape K (2014). The Evolving Role of Molecular Markers in the Diagnosis and Management of Diffuse Glioma. Clinical Cancer Research 20, 5601-5611.

Turkalp Z, Karamchandani J & Das S (2014). IDH Mutation in Glioma. JAMA Neurology 71, 1319.

Waitkus M, Diplas B & Yan H (2015). Isocitrate dehydrogenase mutations in gliomas. Neuro-Oncology 0, 1-11.

If anyone has any suggestions as to how to conduct this edit or what to add please let me know! Mbanting (talk) 21:59, 10 October 2015 (UTC)[reply]

I added a great deal to there article, but am unsure about whether I should move it to mainspace. Here is a link to my sandbox should anyone want to further improve the article : https://en.wikipedia.org/wiki/User:Mbanting/sandbox

Mbanting (talk) 17:06, 10 January 2016 (UTC)[reply]

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Mbanting.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 12:16, 18 January 2022 (UTC)[reply]

[1] Das, Sunit; Karamchandani, Jason (October 2014). "IDH Mutation in Glioma". JAMA Neurology. 71 (10): 1319-1325. {{cite journal}}: |access-date= requires |url= (help)

[1]

Talk:IDH1

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Wiki Education Foundation-supported course assignment

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