Talk:Hemagglutinin

Redirect

I were redirected to this article from HA-tag, but I could not figure out what exactly is a HA-tag now. (B.Mothes (talk) 13:56, 24 August 2010 (UTC))

I suspect that HA-tag should be directing you to Hemagglutination assay. I plan to give this whole set of pages a clear up as soon as i get time >.< Abergabe (talk) 14:35, 24 August 2010 (UTC)

Cold and warm hemagglutinin

The article states the following with no citations:

"There are different types of hemagglutinin but in general, two groups can be described, depending on how they act in different temperatures:

• Cold hemagglutinin: acts in an optimal manner at temperatures reaching 4°C.
• Warm hemagglutinin: acts in an optimal manner at temperatures reaching 37°C."

I hadn't encountered anything about cold or warm hemagglutinin in my research so I left it be as I was editing. The only references I can find on the internet about cold/warm hemagglutinin are in reference to autoimmune hemolytic anemia. From my understanding, the disorder, though involving cold/warm variants and agglutination, does not involve hemagglutinins as the disorder is autoimmune - am I incorrect in my understanding or should the text be removed from the article? ꧁꧂ (talk) 07:57, 15 July 2022 (UTC)

I think the confusion is around the definition of hemagglutinin. The article provides a definition of hemagglutinin in the molecular biology/virology sense, but not in a hematological sense. With that said, it may be prudent to update the opening paragraph to a broader definition of hemagglutinin. Hemagglutinin's in hematology/immunohematology refer to antibodies that are able to cause red blood cell agglutination. Although the Wikipedia article on the topic is called "Cold agglutinin disease", many textbooks refer to the disease as "Cold hemagglutinin disease". Example: Modern Blood Banking & Transfusion Practices, 7th edition. Denise Harmening ISBN-10: 0803668880 LabRatDad (talk) 14:31, 7 September 2022 (UTC)