Talk:HIV/AIDS research

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Lack of references

I just created this article as a sort of list to many different articles which each represent fields of HIV/AIDS research. I provided no references in most cases. This article should have references, but there are references on each of the main articles referenced. Representative references from each of those articles should be migrated here. Blue Rasberry (talk) 22:44, 23 March 2013 (UTC)[reply]

Mellitin

I have updated this page to include a recent Washington University study into mellitin, with reference to the study. This is briefly mentioned in the main article for Mellitin, but I believe it deserves mention on this page too. I am however not a seasoned editor, so if anybody could improve and update to bring it up to standard, that would be great.21stcenturypolitix (talk) 15:34, 5 April 2013 (UTC)[reply]

CD4bs antibody N6

New research published Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

"One patient's blood might hold a new weapon against HIV". this patient, called Z258, ... has natural immunity to the virus. His immunity is a little different than the famous Berlin Patient, who received a bone marrow transplant from someone who has T cells HIV can't bind to — and thus can't infect. Instead, patient Z258's blood contained immune proteins called antibodies that block the virus from infecting cells, and they can neutralize a whopping 98 percent of the de-clawed HIV virus strains the scientists generated in the lab. These antibodies could even block strains that other, similar antibodies were powerless against. Even though HIV was detectable in his blood and he wasn't being treated at the time, this patient had normal T cell levels after more than two decades of infection. The researchers named the antibody N6...

"Scientists have identified an antibody that neutralises 98% of HIV strains". The researchers tracked its evolution over time to see how it responded to the shape-shifting defences of the HIV virus, and found that it relied less on binding with parts of the virus that are prone to changing - known as the V5 region - and more on parts that change very little across different strains. By attaching to these more consistent parts of the virus, N6 is able to prevent HIV from attaching itself to a host's immune cells and attacking them - which is what makes HIV-positive people so vulnerable to AIDS.

"New Antibody Neutralizes 98% of HIV Strains". ...N6 evolved a unique mode of binding that depends less on a variable area of the HIV envelope known as the V5 region and focuses more on conserved regions, which change relatively little among HIV strains. This allows N6 to tolerate changes in the HIV envelope, including the attachment of sugars in the V5 region, a major mechanism by which HIV develops resistance to other VRC01-class antibodies. J mareeswaran (talk) 16:40, 20 November 2016 (UTC)[reply]

one more - "New Antibody Neutralizes Nearly Every HIV Strain". The prior "record" for HIV neutralization was 90 percent. That came courtesy of an antibody known as VRC01, which is currently be assessed for clinical applications. The new antibody, known as N6, is so effective because of its targeting of a region (known as V5) found on the HIV viruses exterior envelope that is very often conserved across the pathogen's evolution—it remains constant, relatively. N6 has a couple of other advantages. One, it's particularly effective against HIV strains that have become resistant to antibodies in the same antibody class. Two (but very related to the above), it's structurally built to evade a common defensive mechanism wielded by the HIV virus called a steric clash J mareeswaran (talk) 10:12, 23 November 2016 (UTC)[reply]

Did the person who had HIV who was thought to have been cured die?

Did the person who had HIV who was thought to have been cured die? I thought I heard this recently in some video. R.I.P., if so. 2601:601:9C00:FB0:4112:5353:BE4:4882 (talk) 00:18, 9 October 2020 (UTC)[reply]

Wiki Education assignment: Adv Molecular Bio Bass-FSU-Fa23

This article was the subject of a Wiki Education Foundation-supported course assignment, between 28 August 2023 and 15 December 2023. Further details are available on the course page. Peer reviewers: Msp20bt.

— Assignment last updated by AWD20 (talk) 14:37, 31 October 2023 (UTC)[reply]