Talk:Evolocumab

Could add clinical trials, side effects and cost

Could add info on clinical trials, side effects and cost - especially since it is being promoted as having fewer side-effects than statins. - Rod57 (talk) 14:04, 11 April 2016 (UTC)

eg the FOURIER trial only showed a 1.5% to 2% absolute risk reduction for various CV endpoints, and the price is still as high.FOURIER Opens ACC With a Bang - Big LDL reduction, prevents MI, but with big price tag - Rod57 (talk) 18:34, 2 December 2017 (UTC)

New wider approval

Repatha Wins FDA Approval for Stand-Alone CVD Prevention - Rod57 (talk) 18:34, 2 December 2017 (UTC)

Deaths covered up

https://bmjopen.bmj.com/content/12/12/e060172 implies that there was fraud and deaths were covered up. I could use some help covering the issue in the article. I see this kind of shit over and over; I fear my anger may come across in my contributions if I edit directly. (No, no COI, just sick of corruption in medicine.) RudolfoMD (talk) 07:32, 24 October 2023 (UTC)

@RudolfoMD: Individual studies can be used sometimes and with caution in editing health-related articles on Wikipedia, but the recommendations of MEDRS should be kept in mind.

If you want to propose a change here, on the talk page, rather than editing the article directly, it would allow other editors to weigh in and see if a consensus can be found. — jmcgnh^{(talk) (contribs)} 08:12, 24 October 2023 (UTC)

Good advice/valid points. Consensus - another reason to seek help. https://bmjopen.bmj.com/content/12/12/e060172.responses has several comments on the paper. In the last one, Amgen was asked to release more info - back in January. Perhaps they have. If so, that would be reassuring; if not, that's a red flag.

Is Altrimetric itself a better source for saying that concerns about mortality rate reporting in the FOURIER study attracted some controversy in the media - https://bmj.altmetric.com/details/140671672/news? You urge me to propose a change, so perhaps saying just that/something like that?

Or should the industry news articles be used, or something else said? (Seems clear these are not the general news media MEDRS discourages.) RudolfoMD (talk) 23:29, 24 October 2023 (UTC)

Just a note, I have closed the {{help me}}, as this has become a consensus-building process and no longer a one-off help request. I have cross-posted at WT:MED to hopefully get more involvement. Primefac (talk) 08:38, 26 October 2023 (UTC)