Talk:Eosinophilia
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 | The contents of the Hypereosinophilia page were merged into Eosinophilia on 19 December 2020. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
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Merge Hypereosinophilia into Eosinophilia
The given difference between Eosinophilia and Hypereosinophilia is a slightly different threshold (500/μl versus 1,500/μL), otherwise these articles are basically repeating the same causes. Even if there was any text specifying that some causes generally only manifest as less than 500/μl or more than 1,500/μL, such text could still be given in a single article. In fact, neither of the articles seem to attempt such a distinction. As given in Hypereosinophilia, there are in fact several grades ("Informally, blood eosinophil levels are often regarded as mildly elevated at counts of 500–1,500/μL, moderately elevated between 1,500–5,000/μL, and severely elevated when greater than 5,000/μL"), and it seems they can all be explained in one single article. Mikael Häggström (talk) 11:43, 3 January 2020 (UTC)
Pathophysiology
The first sentence/paragraph of the Pathophysiology section (IgE-mediated eosinophil production is induced by compounds released by basophils and mast cells, including eosinophil chemotactic factor of anaphylaxis, leukotriene B4 and serotonin mediated release of eosinophil granules occur, complement complex (C5-C6-C7), interleukin 5, and histamine (though this has a narrow range of concentration)) is ungrammatical and difficult to comprehend. Unfortunately, I don't have enough subject-matter knowledge to fix it. Peter Chastain [¡hablá!] 14:37, 16 January 2021 (UTC)
Fungi that induce eosinophylia
I have the following content of the article transferred on the talk page: Asymptomatic eosinophilia, as an adverse reaction to maitake mushrooms[1] I think there are several reasons to do so:
- it is phase II trial (i.e. a preliminary study),
- eosinophylia occured in 4 cases out of 18,
- it is not clear if this eosinophylia is a desirable effect or a side effect,
- there is a study [2] that accounts the effect for beta-D-glucan (a component of many fungi, not only Grifola frondosa).
References
- ^ Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother. (2015) 64:237–247. https://pubmed.ncbi.nlm.nih.gov/25351719/
- ^ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781688/
Tosha Langue (talk) 11:10, 13 December 2023 (UTC)