Talk:Discovery and development of TRPV1 antagonists

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Hopur2-2009 (talk) 12:48, 12 November 2009 (UTC)[reply]

Taste

What do TRPV1 antagonists taste like? Do they all taste spicy like capsaiscin? Or is that particular chemical an agonist? And if so, do these antagonists block the ability to taste spicy foods..? Anxietycello (talk) 02:39, 3 January 2010 (UTC)[reply]

Not only are they not spicy, but if you manage to reach complete inhibition of TPRV-1 you could ingest pure capsiacin and not feel the effects. Capsciacin is only a partial(low efficacy)agonist, and most antagonist drugs bind to the protein with much higher affinity (potency.)Though you should be warned, doing so will cause you to run a terrible fever. Jgcimino (talk) 23:17, 13 November 2011 (UTC)[reply]

Review of TRPV1 targets

This article in Nature Reviews Drug Discovery 10, 601-620 (August 2011) is slightly more timely than the chart of Clinical trials in the current page.

Table: http://www.nature.com/nrd/journal/v10/n8/fig_tab/nrd3456_T1.html

Timetraveler3.14 (talk) 20:44, 27 September 2015 (UTC)[reply]

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