Talk:DNA methylation

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Visual aids

This page should have visual aids to make the attachment location of the methyl groups more easily understood 173.20.25.72 (talk) 15:30, 13 June 2011 (UTC)[reply]

Reference for consideration

Tada, Yasuhiro (2006). "Epigenetic Modulation of Tumor Suppressor CCAAT/Enhancer Binding Protein {alpha} Activity in Lung Cancer". Journal of the National Cancer Institute. 98 (6): 396–406. doi:10.1093/jnci/djj093. PMID 16537832. Retrieved 2006-05-05. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)

Action of DNA methylation in modulating gene activity can take place at remote sites in addition to or in preference to promoter-proximal locations. Though one news article reports this as 'unexpected', it's not really considering the known role for remote enhancers, locus control regions and other regulatory islands. User:Ceyockey (talk to me) 02:59, 6 May 2006 (UTC)[reply]

Tag removed

This page has been tagged as being too technical for most readers to understand since November of 2008, but the present page has been greatly improved since then, so I am removing the tag. Guy Macon (talk) 03:26, 5 March 2011 (UTC)[reply]

Opening

A poor sentence: "As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism." I don't like "as such" anywhere. I don't think a mechanism is part of the code. I am not certain we know enough to assert there is a singular epigenetic code deserving a definite article, rather than code which is adjectively epigenetic; I have no view on how well-characterised it is by comparison with other mechanisms reading and writing the epigenetic code, but in the absence of a clear indication of such a comparison, that may be better left out. "It is one of the mechanisms implementing epigenetic code" might do? with mechanisms linked to (epigenetic mechanisms) and (epigenetic code) if or when such articles are standing alone. It looks an important topic. Midgley (talk) 22:01, 29 November 2008 (UTC)[reply]

The very opening paragraph is still too technical imo, that of a former news reporter for the Gannett news org.:

"DNA methylation is a biochemical process that is important for normal development in higher organisms. It involves the addition of a methyl group to the 5 position of the cytosine pyrimidine ring or the number 6 nitrogen..."

I think this paragraph may be suitable further on in the article, but details like "...the number 5 position of the cytosine pyrimidine ring or the number 6 postition of the adine purine ring (cystosine and adenine are two of the four...)..." are too technical for the intro paragraph and would stymie many readers. Eternal Vigilante (talk) 16:26, 3 September 2011 (UTC)[reply]

Memory

DNA methylation may regulate memory, but it doesn't encode memories directly. I've altered the language to fix this. The New Scientist article really shouldn't be cited here, as it's pop-sci and not a primary source. --aciel (talk) 03:16, 23 January 2009 (UTC)[reply]

AfD: Illumina Methylation Assay

An expert opinion on notability would be useful at Wikipedia:Articles_for_deletion/Illumina_Methylation_Assay -- Jheald (talk) 15:25, 12 October 2009 (UTC)[reply]

Discovery

I would like to see more on the story of the discovery that DNA methylation was possible and that it does happen. Zaphraud (talk) 04:57, 21 January 2012 (UTC)[reply]

For consideraton -- persistence of DNA methylation

http://www.sciencedaily.com/releases/2013/07/130705102037.htm In part: "Salk researchers previously discovered that in human embryonic stem cells and induced pluripotent stem cells, a type of artificially derived stem cell, DNA methylation can also occur when G does not follow C, hence "non-CG methylation." Originally, they thought that this type of methylation disappeared when stem cells differentiate into specific tissue-types such as lung or fat cells. The current study finds this is not the case in the brain, where non-CG methylation appears after cells differentiate, usually during childhood and adolescence when the brain is maturing." -- Jo3sampl (talk) 12:03, 6 July 2013 (UTC)[reply]

Further additions could be for a subheading of autoimmune diseases and a correlation between methylation of genes, say, associated with SLE and RA development. This is just one of the many articles detailing the connection: http://www.ncbi.nlm.nih.gov/pubmed/22536485 166.137.246.114 (talk) 21:39, 12 November 2014 (UTC) random person doing epidemiological research for a class.[reply]

Assessment comment

The comment(s) below were originally left at Talk:DNA methylation/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

This article is a barely adequate description of eukaryotic DNA methylation. However, there is no mention of prokaryotic DNA methylation! This is an equally important topic, and should be mentioned in the article. Also, DNA it focused exclusively on higher eukaryotes; lower eukaryotes have somewhat different methylation, often using methyl-adenine for instance (similar to bacteria). The idea that this has evolved during the metazoan radiation is important, and without discussing this variability, that point is missed.

Last edited at 12:24, 21 February 2015 (UTC). Substituted at 12:40, 29 April 2016 (UTC)

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Misshaped DNA remainder to have meiotic prophase I sectioning impact

It's been proposed that histones and DNA methylation cause:

the homologous recombination during meiotic prophase I not to be random due to the remaining misshape of the DNA (statistics aren't neutral).

This shouldn't normally happen. We all know that. "Shouldn't normally happen" is a dialectic phrase. We need proof in the lab, we cannot simply imagine that all goes statistically well. We should test it on corn and microorganisms. — Preceding unsigned comment added by 2A02:2149:841A:3C00:E933:DA24:7618:BE11 (talk) 02:44, 22 December 2017 (UTC)[reply]

wrong substitution?

The below sentence in the article, shouldn't it be "substitute A for G"? I wish to mean A arrives and G departs, which is what I think happens. So T:G becomes T:A

"This results in a T:G mismatch. Repair mechanisms then correct it back to the original C:G pair; alternatively, they may substitute G for A, turning the original C:G pair into a T:A pair, effectively changing a base and introducing a mutation" Polypipe Wrangler (talk) 04:40, 14 February 2020 (UTC)[reply]

article on OSK-induced reprogramming

Concerning DNA methylation, there's an article that reports on axon regeneration and vision in mice based on Oct4, Sox2 and Klf4 genes (OSK)-induced reprogramming.(Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA (December 2020). "Reprogramming to recover youthful epigenetic information and restore vision". Nature. 588 (7836): 124–129. doi:10.1038/s41586-020-2975-4. PMID 33268865.) Would any of the experts here care to work that into the article in an appropriate place? Thank you --Chris Howard (talk) 22:05, 6 December 2020 (UTC)[reply]