Talk:DKK1
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name
Where did the name of this protein come from? It means "dickhead" in English+German!
- Btw, to whoever wrote that above comment: I am not a German speaker, but it is my understanding that it means 'big/thick' head because of the phenotype of larger heads in mice overexpressing Dkk1 (Glinka et al., 1998).Gvbdxz (talk) 09:28, 15 September 2017 (UTC)
- I am German. "ein Dickkopf sein" = "to be stubborn". Could also mean hydrocephalus? The head is larger than the body. Or the head in affected specimen is larger than in not affected specimen? Could be a family name? --Dr. Hartwig Raeder (talk) 18:02, 13 August 2018 (UTC)
New sections
This article needs to be updated based on recent publications. There's a new receptor identified, so much more information on roles in pathology and data on how Dkk1 both has a role in survival and in cell death through different mechanisms. Gvbdxz (talk) 09:28, 15 September 2017 (UTC)
Fasudil & amyloid-beta
New research may answer why many recent Alzheimer's clinical trials have failed mentions its effect on amyloid-beta formation can be blocked with fasudil. - Rod57 (talk) 17:35, 29 September 2018 (UTC)