Talk:Cas12a

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Untitled

Hello friends, I will be editing this Wikipedia entry for next few month. — Preceding unsigned comment added by Oscarjuez (talk • contribs) 07:48, 26 February 2016 (UTC)[reply]

Hopefully! "Since cells must protect themselves against a host of viruses (to remove viral DNA), it has been hypothesized that each such virus has a complementary endonuclease," indicates some serious misunderstanding or missing proof reading... Yak90 (talk) 00:09, 18 April 2016 (UTC)[reply]

This article has the tone of someone who has a vendetta against cas9. — Preceding unsigned comment added by 205.133.149.254 (talk) 21:06, 29 January 2017 (UTC)[reply]

I agree with above, some of it sounds like ad-copy. I don't have a particular horse in this race but I'm going to try to note any real/potential challenges with Cpf1 and advantages/disadvantages compared to various site-specific nucleases. Although the more I looked through the research the cooler Cpf1 seems. Krb19 (talk) 22:18, 27 December 2018 (UTC)[reply]

Source number four has no link?Tanner Stenlund (talk) 20:42, 28 May 2020 (UTC)[reply]

Move

Isn't CRISPR-Cas12 / CRISPR-Cas12a the same as cpf1 ? So isn't a rename in order ? See https://innovativegenomics.org/resources/educational-materials/glossary/cpf1-cas12/ and http://science.sciencemag.org/content/early/2018/02/14/science.aar6245 KVDP (talk) 08:17, 27 March 2018 (UTC)[reply]

I think Cas12a should redirect to Cpf1 129.215.47.59 (talk) 11:05, 16 May 2018 (UTC)[reply]

I'm pretty sure Cas12a is now the preferred term. Google scholar says that in the past 2 years, 6500 with "cas12a" and 1400 papers with "cpf1", and more with "cas12". I propose changing the article name to "Cas12a (Cpf1)" (and as opposed to current format of "CRISPR/Cpf1" to match the format of "Cas9"). Here is the paper[1] which (I think) first proposed the name change, based on sequence/structure homology (Cas12a/Cpf1 is essentially a Cas9 variant with a significant subunit/domain deletion, hence the small size).

06/19/2021; I believe I wrote the above in ~2019 but failed to sign it -- Krb19
I agree that a name move is useful. I never see cpf1 unlike cas12(a). — Preceding unsigned comment added by Vctrbarbieri (talk • contribs) 12:50, 23 October 2020 (UTC)[reply]

I also think the name should be updated to CRISPR/Cas12, but I'm not sure how to edit the page name. All the literature I've seen recently has used Cas12 exclusively (though some mention the old name). AlkalineCoffee (talk) 01:51, 9 March 2021 (UTC)[reply]

I have now renamed/moved the page to CRISPR/Cas12a and replaced most of the appearances of Cpf1 --> Cas12a in the body. Thanks everyone for your input. Krb19 (talk) 11:50, 19 July 2021 (UTC)[reply]

References

  1. ^ Shmakov, Sergey; Smargon, Aaron; Scott, David; Cox, David; Pyzocha, Neena; Yan, Winston; Abudayyeh, Omar O.; Gootenberg, Jonathan S.; Makarova, Kira S. (03 2017). "Diversity and evolution of class 2 CRISPR-Cas systems". Nature Reviews. Microbiology. 15 (3): 169–182. doi:10.1038/nrmicro.2016.184. ISSN 1740-1534. PMC 5851899. PMID 28111461. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)

Proposed merge of Cpf1 into CRISPR/Cas12a

Same endonuclease invlolved. Cpf1 article is strict subset of Cas12a article: former talks about bioengineering only, latter talks about that and more. Artoria2e5 🌉 03:40, 10 September 2021 (UTC)[reply]

I am going to BOLD it seeing there is a recent discussion. --Artoria2e5 🌉 06:05, 10 September 2021 (UTC)[reply]

Requested move 25 February 2022

The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion.

The result of the move request was: moved. (closed by non-admin page mover) Vpab15 (talk) 22:46, 6 March 2022 (UTC)[reply]

CRISPR/Cas12a → Cas12a – Avoid subpage of CRISPR, consistent with Cas1 and Cas9. Taylor 49 (talk) 19:59, 25 February 2022 (UTC)[reply]

Comment Subpages are not enabled in article space. 🐶 EpicPupper (he/him | talk) 19:58, 5 March 2022 (UTC)[reply]
Comment 2: But it enabled on Article talk pages. Like this one is a subpage of Talk:CRISPR. Not like this alone is good reason to move but still. ---CX Zoom(he/him) (let's talk|contribs) 09:39, 6 March 2022 (UTC)[reply]
Support then, the consistency makes it enough to move. 🐶 EpicPupper (he/him | talk) 16:40, 6 March 2022 (UTC)[reply]
The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.
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