Talk:Beta-2 adrenergic receptor

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Effect on Arteries of Skeletal Muscle

It doesn't say "dilates". I'm assuming an omission. Can anyone confirm that activation of beta-2 receptors dilates arteries to skeletal muscle? Horus (talk) 04:54, 27 October 2008 (UTC)[reply]

Assessment comment

The comment(s) below were originally left at Talk:Beta-2 adrenergic receptor/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Why formoterol is not listed as a b2 adrenergic agonist? I'm not on this field, so I'm not comfortable adding it to the list.

Last edited at 12:44, 29 April 2008 (UTC). Substituted at 09:32, 29 April 2016 (UTC)

Clean up the introduction

the introduction isn't easy to read, e.g. instead of "ligand synonym adrenaline" use "epinephrine(adrenaline)". I have made small changes to it, I would be grateful for feedback.CaffeineWitcher (talk) 13:42, 17 May 2020 (UTC)[reply]

Link with Potassium channels

I stumbled upon a link between β2-adrenergic receptors and potassium channels.

Galaz-Montoya, Monica; Wright, Sara J.; Rodriguez, Gustavo J.; Lichtarge, Olivier; Wensel, Theodore G. (2017-06-16). "β2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway". The Journal of Biological Chemistry. 292 (24): 9967–9974. doi:10.1074/jbc.M117.787119. ISSN 1083-351X. PMC 5473248. PMID 28442571.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Clausen, T.; Flatman, J. A. (1977). "The effect of catecholamines on Na-K transport and membrane potential in rat soleus muscle". The Journal of Physiology. 270 (2): 383–414. doi:10.1113/jphysiol.1977.sp011958. ISSN 0022-3751. PMC 1353519. PMID 198530.

Jacobus, A. P.; Rodrigues, D. O.; Borba, P. F.; Loss, E. S.; Wassermann, G. F. (2005). "Isoproterenol opens K+(ATP) channels via a beta2-adrenoceptor-linked mechanism in Sertoli cells from immature rats". Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 37 (4): 198–204. doi:10.1055/s-2005-861414. ISSN 0018-5043. PMID 15952077.

It is relevant that it has a link with some medication inducing hypokalemia. (see the edits I did on that page.)

I just had not the time yet to understand the exact channels that are affected. If someone has more time and speed, it would be nice to add this info to wikipedia. Otherwise I will dig into the articles later. —Arthurfragoso (talk) 02:34, 4 June 2022 (UTC)[reply]

Relation to pH

Another thing I stumbled upon: This article^[1] that uses^[2] as source. It mentions the procedure carboxytherapy, and it says that when CO2 is infused, it lowers the lowers the local pH, and by doing so it would stimulate β2-adrenergic receptors bringing a local vasodilation. I was then wondering about how valid those claims are, unfortunately I can't access the source they use. But I found ^[3] that suggest this receptor has a higher agonist activation at lower pH.

I immediately thought it could have a whole in the blood acid–base homeostasis, but as there isn't much articles covering β2AR pH relation, then maybe it doesn't have much impact or relevance on the acid–base homeostasis.

References

^ de Andrade, RC; de Carvalho, JMFR (2020). "Rejuvenescimento facial e as "novas tecnologias"". Diálogos em Saúde (in Portuguese). 2 (1). ISSN 2596-206X.
^ Dutra, Patrícia Gontijo Moura; Lombardo, Miguel Angel Martinez (Jun 2011). Medicina estética, abordaje terapéutico (in Spanish). Médica Panamericana. p. 436-9. ISBN 978-84-9835-385-3.
^ Ghanouni, Pejman; Schambye, Hans; Seifert, Roland; Lee, Tae Weon; Rasmussen, Søren G.F.; Gether, Ulrik; Kobilka, Brian K. (2000-02-04). The Effect of pH on β2 Adrenoceptor Function. Vol. 275. pp. 3121–3127. doi:10.1074/jbc.275.5.3121. ISSN 0021-9258. PMID 10652295.{{cite book}}: CS1 maint: unflagged free DOI (link)

— Arthurfragoso (talk) 17:58, 29 May 2023 (UTC)[reply]

There is no hole in the principle of acid–base homeostasis. Since tissue is perfused with serum which in turn is also buffered, infusing carbon dioxide into tissue is not likely to change pH signficantly. I am highly skeptical that this treatment could activate β2-adrenergic receptors by changing pH. Boghog (talk) 18:30, 29 May 2023 (UTC)[reply]

[1] Andrade, RC; de Carvalho, JMFR (2020). "Rejuvenescimento facial e as "novas tecnologias"". Diálogos em Saúde (in Portuguese). 2 (1). ISSN 2596-206X.

[2] Dutra, Patrícia Gontijo Moura; Lombardo, Miguel Angel Martinez (Jun 2011). Medicina estética, abordaje terapéutico (in Spanish). Médica Panamericana. p. 436-9. ISBN 978-84-9835-385-3.

[3] Ghanouni, Pejman; Schambye, Hans; Seifert, Roland; Lee, Tae Weon; Rasmussen, Søren G.F.; Gether, Ulrik; Kobilka, Brian K. (2000-02-04). The Effect of pH on β2 Adrenoceptor Function. Vol. 275. pp. 3121–3127. doi:10.1074/jbc.275.5.3121. ISSN 0021-9258. PMID 10652295.{{cite book}}: CS1 maint: unflagged free DOI (link)

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