Talk:Artificial transcription factor

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 27 September 2021 and 3 December 2021. Further details are available on the course page. Student editor(s): Owenwilborn. Peer reviewers: Emilyrd77, Emribo3.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 14:48, 16 January 2022 (UTC)

clinical significance

Are there any clinical trials of ATFs ? or any preclinical work ? or any diseases thought to be amenable to treatment with ATFs ? Rod57 (talk) 03:09, 24 January 2009 (UTC)

Starting Point References

Hi All,

My name is Owen Wilborn and I am undergraduate engineering student at UCLA. Over the next 3 weeks I plan on making improvements to this article. Below are four good starting references I will be using.

ATF = Artificial Transcription Factor

Reprogramming cell fate with artificial transcription factors - https://pubmed.ncbi.nlm.nih.gov/29389011/ –Secondary source reviewing different ATF types (CRISPR-Cas, TALEs, Synthetic Molecules, Zine Fingers) and their function in changing cell state. Angelman syndrome: Current and emerging therapies in 2016 - https://pubmed.ncbi.nlm.nih.gov/27860204/ –Secondary source covering zinc finger proteins ATFs which bind to and repress UBe3a-As. Provides an example of a possible treatment using ATFs. Modular design of artificial transcription factors - https://pubmed.ncbi.nlm.nih.gov/12470729/ –Secondary source, covers all the basics of what an ATF is, how it works, and how to design one. CRISPR-dCas9-Based Artificial Transcription Factors to Improve Efficacy of Cancer Treatment With Drug Repurposing: Proposal for Future Research - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887379/ –Secondary source, covers CRISPR based ATFs and their application in cancer treatment

Please add to this list if you have any other good references or contact me if you have any questions about improving the article/want to work together on it.

Owenwilborn (talk) 06:00, 13 October 2021 (UTC)

Emily D. Peer Review

Hi Owen,

I have completed my peer review of your article. Overall, very nice job! There is some room for improvement by adding more information to the applications sections and clarifying the ATF DNA-Binding Domain which I detail in my peer review, please take a look.

Best, Emily D. --Emilyrd77 (talk) 14:53, 27 October 2021 (UTC)