Talk:Agranulocyte

Merge with PBMC and Mononuclear leukocytes

Are agranulocytes the same as PBMC? Should these articles be merged? --LasseFolkersen 10:59, 25 September 2006 (UTC)

Looks like they're closely related, and the agranulocyte page is still considered a stub. I'd also propose that Mononuclear leukocytes merges into agranulocyte at the same time. I think "agranulocyte" is the more common of the three terms. Monocytes can apparently be granular (according to this page - search for "kidney") but they're apparently still agranulocytes, and I think the same goes for mast cells and natural killer cells. I suspect agranulocyte has come to mean "any leukocyte that's not a basophil, eosinophil or neutrophil" by convention, but I'm not comfortable doing the merge without knowing for sure. Perhaps we need an expert. For now I'll just tag all three with the merge template so people can see they're related and need attention. Zak (talk) 22:34, 6 February 2010 (UTC)

I have studied and worked in immunology for a few years now and I have never heard of the term 'agranulocyte'! If you merge them, I would put everything under 'mononuclear leukocyte' or 'PBMC' and have the others redirect there.

Same for me, I have a PhD in medical cell biology and did my thesis in the field of diabetes immunology and have never heard the term "agranulocyte". "PBMC" is a commonly used term, though. — Preceding unsigned comment added by 81.224.161.56 (talk) 15:39, 2 October 2011 (UTC)

I am doing a master in biology. I actually never heard of PMBC before, and can't find it on the French wikipedia. My immunology teacher told us that (in french) 'agranulocyte' is an archaic word used vs 'granulocyte' (still used, = eosinophils, neutrophils and basophils). So 'agranulocyte' might be an archaism in English too...? 91.179.48.55 (talk) 16:29, 5 November 2011 (UTC)

I also believe the term is archaic. It is still used in Spanish, albeit it will surely be overshadowed by the more recent and perhaps accurate terms. FoCuSandLeArN (talk) 20:40, 3 June 2012 (UTC)

"PBMC" is still commonly used in the lab. My wife works on infiltrating PBMCs in HIV peripheral nerve, and that's the terminology that most everyone uses. NeuroJoe (talk) —Preceding undated comment added 14:06, 8 November 2012 (UTC)

Monocytes are granulocytes

I'm not sure where the idea that monocytes are agranulocytes came from. There's a source here that clearly states they're granular, and the wiki page on monocytes says they have granules as well. Granulated monocytes also agrees with the hematopoietic lineages, and there's no reason for them not to have granules, since everything in the lineage has them as well. Perhaps this misconception derives from the above commentary that "agranulocyte" is an uncommon and poorly defined term. Daemyth (talk) 01:23, 4 May 2016 (UTC)

   Adding again to the above after some further research, it seems that there's a false correlation between having a simple nucleus with one lobe and missing granules, and respectively between having a polymorphonucleus and containing granules. Monocytes and macrophages seem to be the counterexample here; they are mononuclear and also have granules. Daemyth (talk) 02:34, 4 May 2016 (UTC)

References

T cells are not the only cells with immune memory

This article is misleading. While the statement that T cells cells are crucial to the immune system due to its immune memory is not false, the exclusion of B cells and even natural killer cells from the concept of immune memory creates the impression that T cells alone are responsible for immune memory. Any reader that reads this page will come away from it, thinking that T cells are the only part of the immune system that has facilitates immune memory. 197.229.2.247 (talk) 19:10, 23 February 2022 (UTC)