Recombinant factor IX

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Not to be confused with Coagulation factor IX complex or Factor IX concentrate.
Recombinant factor IX
Names
Trade namesBenefix, Rixubis,[1] Ixinity, Alprolix Idelvion, Rebinyn, others
Other namesCoagulation factor IX; recombinant factor IX; nonacog alfa; albutrepenonacog alfa; eftrenonacog alfa; nonacog beta pegol
Clinical data
Main usesHaemophilia B[1]
Side effectsFever, cough, pain at the site of injection, nausea, allergic reactions[2][3]
External links
AHFS/Drugs.comMonograph

Recombinant factor IX, also known as nonacog alfa among others, is a medication used to treat haemophilia B.[1] Specifically it is used to treat and prevent bleeding.[1] Its use improves quality of life.[1] It is given by slow injection into a vein.[1]

Common side effects include fever, cough, pain at the site of injection, and nausea.[2] It may also result in allergic reactions including angioedema, hives, wheezing, or low blood pressure.[3] Antibodies that block its ability to work may also develop.[3] It is a manufactured version of the blood clotting enzyme factor IX, made by recombinant methods.[1]

Recombinant versions were approved for medical use in the United States and Europe in 1997.[2][3][4] It is on the World Health Organization's List of Essential Medicines.[5] In the United Kingdom 1,000 units costs the NHS about £600 as of 2023.[6] This amount in the United States costs about 1,600 USD.[7] There are also versions made from human plasma, but these are associated with risks of infection.[8][6][4]

Types

Recombinant factor IX formulations include:

  • nonacog alfa (brand name BeneFix)[3]
  • albutrepenonacog alfa (brand name Idelvion)[9]
  • eftrenonacog alfa (brand name Alprolix)[10]
  • nonacog beta pegol (brand name Refixia)[11]

History

Factor IX concentrates were developed from human plasma in the late 1960s.[4] Recombinant versions came into medical use in 1997.[4] In the 1950s and 1960s fresh frozen plasma (FFP) was often used.[4]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Factor IX (Recombinant) (Monograph)". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 24 September 2017. Retrieved 12 September 2023.
  2. ↑ 2.0 2.1 2.2 "BENEFIX (coagulation factor ix- recombinant kit". Dailymed. Archived from the original on 29 January 2023. Retrieved 12 September 2023.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 "BeneFIX EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 17 June 2020. Retrieved 17 June 2020.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 "Hemophilia: From Plasma to Recombinant Factors". 2008. Archived from the original on 29 May 2023. Retrieved 13 September 2023.
  5. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  6. ↑ 6.0 6.1 "Factor IX fraction, dried [Specialist drug] Medicinal forms". BNF. Archived from the original on 13 September 2023. Retrieved 13 September 2023.
  7. ↑ "Benefix". GoodRx. Retrieved 13 September 2023.
  8. ↑ "Haemonine 500 / Haemonine 1000". EMC. Archived from the original on 11 April 2022. Retrieved 13 September 2023.
  9. ↑ "Idelvion EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 17 June 2020. Retrieved 17 June 2020.
  10. ↑ "Alprolix EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 11 August 2020. Retrieved 17 June 2020.
  11. ↑ "Refixia EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 18 June 2020. Retrieved 17 June 2020.

External links

Retrieved from "https://mdwiki.org/w/index.php?title=Recombinant_factor_IX&oldid=1368199"