Prussian blue (medical use)
|Trade names||Radiogardase, others|
|Main uses||Thallium poisoning, radioactive cesium poisoning|
|Side effects||Constipation, low blood potassium, dark stools|
|Defined daily dose||Not established|
|Chemical and physical data|
Prussian blue, also known as potassium ferric hexacyanoferrate, is used as a medication to treat thallium poisoning or radioactive cesium poisoning. For thallium it may be used in addition to gastric lavage, activated charcoal, forced diuresis, and hemodialysis. It is given by mouth or nasogastric tube. Prussian blue is also used in the urine to test for G6PD deficiency.
Side effects may include constipation, low blood potassium, and stools that are dark. With long-term use, sweat may turn blue. It works by binding to and thus preventing the absorption of thallium and cesium from the intestines.
Prussian blue was developed around 1706. It is on the World Health Organization's List of Essential Medicines. As of 2016[update], it is only approved for medical use in Germany, the United States, and Japan. In the United States a course of treatment costs more than $200. Access to medical-grade Prussian blue can be difficult in many areas of the world including the developed world.
Prussian blue is used to treat thallium poisoning or radioactive cesium poisoning. It may also be used for exposure to radioactive material until the underlying type is determined.
Often it is given with mannitol or sorbitol to increase the speed it moves through the intestines.
Prussian blue is also used to detect hemosiderin in urine to confirm a diagnosis of G6PD deficiency.
For thallium it may be used in addition to gastric lavage, forced diuresis, and hemodialysis.
It is given until the amount of thallium in the urine drops to below 0.5 mg per day.
It is specifically only used for radioactive caesium poisoning when the caesium has entered the body either by swallowing or breathing it in.
The defined daily dose is not established.
- ↑ 1.0 1.1 1.2 1.3 1.4 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 65. hdl:10665/44053. ISBN 9789241547659.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Prussian Blue". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
- ↑ 3.0 3.1 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 21 October 2020. Retrieved 13 September 2020.
- ↑ 4.0 4.1 4.2 4.3 Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 472. ISBN 9781284057560.
- ↑ 5.0 5.1 5.2 5.3 5.4 Dart, Richard C. (2004). Medical Toxicology. Lippincott Williams & Wilkins. p. 248,279. ISBN 9780781728454. Archived from the original on 2017-01-16.
- ↑ 6.0 6.1 "Glucose-6-phosphate dehyrogenase deficiency — Medlibes: Online Medical Library". medlibes.com. Archived from the original on 2016-09-15. Retrieved 2017-05-03.
- ↑ Hall, Alan H.; Isom, Gary E.; Rockwood, Gary A. (2015). Toxicology of Cyanides and Cyanogens: Experimental, Applied and Clinical Aspects. John Wiley & Sons. p. 43. ISBN 9781118628942. Archived from the original on 2017-01-16.
- ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ↑ Goyer, Robert A. (2016). Metal Toxicology: Approaches and Methods. Elsevier. p. 93. ISBN 9781483288567. Archived from the original on 2017-09-18. Retrieved 2017-01-15.
- ↑ Dobbs, Michael R. (2009). Clinical Neurotoxicology: Syndromes, Substances, Environments. Elsevier Health Sciences. p. 280. ISBN 0323052606. Archived from the original on 2017-01-16. Retrieved 2017-01-15.
- ↑ "Radioaktivität: Berliner Blau als Arzneimittel". Dtsch Arztebl (in Deutsch). 1 July 2011. Archived from the original on 14 December 2018. Retrieved 10 December 2018.
- ↑ Archiver, Truthout (27 June 2011). "Fukushima's Cesium Spew - Deadly Catch-22s in Japan Disaster Relief". Truthout. Archived from the original on 16 January 2017. Retrieved 15 January 2017.
- ↑ "Questions and Answers on Calcium-DTPA and Zinc-DTPA (Updated)". U.S. Food & Drug Administration. Archived from the original on 21 March 2020. Retrieved 21 March 2020.
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