Polyuridylation
Polyuridylation, also called oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA. Cytoplasmic poly(U) polymerases can add uridine nucleotides to both coding and non-coding RNAs. This addition may occur throughout a variety of RNA types including mRNAs, small RNAs, miRNAs, siRNAs, guide RNAs, or piRNAs.[1] Polyuridylation has been shown to play a role in gene regulation as an evolutionarily conserved process in eukaryotes.[2]
One group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail. Polyuridylation of a histone mRNA promotes its degradation, involving the exosome. Other RNAs in Arabidopsis and mouse have been seen to be polyuridinylated after cleavage.[3]
References
- ^ Munoz-Tello P, Rajappa L, Coquille S, Thore S (15 April 2015). "Polyuridylation in Eukaryotes: A 3'-End Modification Regulating RNA Life". BioMed Research International. 2015: 968127. doi:10.1155/2015/968127. PMC 4442281. PMID 26078976.
- ^ Rissland OS, Mikulasova A, Norbury CJ (May 2007). "Efficient RNA polyuridylation by noncanonical poly(A) polymerases". Molecular and Cellular Biology. 27 (10): 3612–3624. doi:10.1128/MCB.02209-06. PMC 1899984. PMID 17353264.
- ^ Wilusz CJ, Wilusz J (January 2008). "New ways to meet your (3') end oligouridylation as a step on the path to destruction". Genes & Development. 22 (1): 1–7. doi:10.1101/gad.1634508. PMC 2731568. PMID 18172159.
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