EDC3

EDC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VC8, 2WAX, 2WAY, 3D3J, 3D3K
Identifiers
Aliases	EDC3, LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
External IDs	OMIM: 609842 MGI: 2142951 HomoloGene: 11827 GeneCards: EDC3
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.1 Start 74,630,558 bp End 74,696,292 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 57,615,823 bp End 57,659,782 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ganglionic eminence islet of Langerhans right lobe of thyroid gland rectum left lobe of thyroid gland monocyte gastrocnemius muscle popliteal artery thymus Top expressed in primitive streak hand otolith organ yolk sac utricle external carotid artery trigeminal ganglion internal carotid artery fossa condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphodiesterase decapping endonuclease activity identical protein binding RNA binding mRNA binding Cellular component cytoplasm cytosol membrane P-body cytoplasmic ribonucleoprotein granule Biological process P-body assembly exonucleolytic catabolism of deadenylated mRNA RNA phosphodiester bond hydrolysis, endonucleolytic deadenylation-independent decapping of nuclear-transcribed mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80153 353190 Ensembl ENSG00000179151 ENSMUSG00000038957 UniProt Q96F86 Q8K2D3 RefSeq (mRNA) NM_001142443 NM_001142444 NM_025083 NM_001351378 NM_001351379 NM_153799 RefSeq (protein) NP_001135915 NP_001135916 NP_079359 NP_001338307 NP_001338308 NP_722494 Location (UCSC) Chr 15: 74.63 – 74.7 Mb Chr 9: 57.62 – 57.66 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell. 20 (6): 905–15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O (2007). "A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting". Mol. Cell. Biol. 27 (24): 8600–11. doi:10.1128/MCB.01506-07. PMC 2169425. PMID 17923697.