Podophyllum resin

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Podophyllum resin
Trade namesPodocon-25, others
Clinical data
Main usesGenital warts, plantar warts[1]
Side effectsRedness, itchiness, pain at the site of use[1]
  • US: X (Contraindicated)
Defined daily doseNot established[2]
External links

Podophyllum resin, also known as podophyllum or podophyllin, is a resin made from the roots of the American mandrake.[3] It is used as a medication to treat genital warts and plantar warts, including in people with HIV/AIDS.[1][4] It is not recommended in HPV infections without external warts.[1] Application by a healthcare provider to the skin is recommended.[1]

Common side effects include redness, itchiness, and pain at the site of use.[1] Severe side effects may include vomiting, abdominal pain, confusion, bone marrow suppression, and diarrhea.[1] It is not recommended for more than a small area at a time.[1] Use during pregnancy is known to be dangerous to the baby.[1] It works mostly via podophyllotoxin which stops cell division.[3]

Podophyllin resin has been used to treat warts since at least 1820.[5] It is on the World Health Organization's List of Essential Medicines.[6] In the United States a course of treatment costs about US$50 to US$100.[7] A formulation known as podophyllotoxin with less side effects is also available.[4]


The defined daily dose is not established.[2]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Podophyllum Resin". The American Society of Health-System Pharmacists. Archived from the original on 22 December 2016. Retrieved 8 December 2016.
  2. 2.0 2.1 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 17 September 2020.
  3. 3.0 3.1 Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2011). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. p. 1190. ISBN 9781608317080. Archived from the original on 2016-12-22.
  4. 4.0 4.1 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 307, 309. hdl:10665/44053. ISBN 9789241547659.
  5. Arora, Rajesh (2010). Medicinal Plant Biotechnology. CABI. p. 36. ISBN 9781845936921. Archived from the original on 2016-12-22.
  6. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  7. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 185. ISBN 9781284057560.

External links

  • "Podophyllum Resin". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2021-08-28. Retrieved 2020-05-17.