PRO 2000

PRO 2000
Clinical data
Other names	2-Naphthalenesulfonic acid, sodium salt, polymer with formaldehyde
Identifiers
	IUPAC name Sodium 2-naphthalenesulfonate, polymer with formaldehyde;
CAS Number	29321-75-3;
ChemSpider	none;
NIAID ChemDB	032942;
CompTox Dashboard (EPA)	DTXSID401011472 ;
ECHA InfoCard	100.111.201
Chemical and physical data
Formula	(C10H8O3S.CH2O.Na)x
Molar mass	Approximately 5 kg/mol

PRO 2000 is an experimental vaginal microbicide which has been proposed as a preventive medicine for reducing the risk of contracting HIV. It has never been recommended as an effective medicine to be used for any purpose. Some clinical trials have shown that under some conditions it may provide some protection against HIV.

History

Endo Pharmaceuticals manufactures the drug.^[1]

Efficacy

Animal testing studies done on macaques have shown that PRO 2000 is effective in preventing the transmission of HIV. Other studies have given supportive evidence that the product is safe in humans and would be an appropriate candidate for testing.^[2]

A phase III clinical trial of 9385 women in sub-Saharan Africa showed that PRO 2000 was not effective in preventing transmission of HIV.^[3]

References

^ "AIDSinfo - HIV/AIDS Drug Information - PRO 2000". aidsinfo.nih.gov. 2011. Archived from the original on October 17, 2011. Retrieved 20 November 2011.
^ Patton DL, Cosgrove Sweeney YT, Paul KJ (October 2008). "A summary of preclinical topical microbicide vaginal safety and chlamydial efficacy evaluations in a pigtailed macaque model". Sexually Transmitted Diseases. 35 (10): 889–97. doi:10.1097/OLQ.0b013e31817dfdb8. PMID 18607310. S2CID 12260211.
^ McCormack S, Ramjee G, Kamali A, Rees H, Crook AM, Gafos M, et al. (October 2010). "PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial". Lancet. 376 (9749): 1329–37. doi:10.1016/S0140-6736(10)61086-0. PMC 2956883. PMID 20851460.

[1] "AIDSinfo - HIV/AIDS Drug Information - PRO 2000". aidsinfo.nih.gov. 2011. Archived from the original on October 17, 2011. Retrieved 20 November 2011.

[2] Patton DL, Cosgrove Sweeney YT, Paul KJ (October 2008). "A summary of preclinical topical microbicide vaginal safety and chlamydial efficacy evaluations in a pigtailed macaque model". Sexually Transmitted Diseases. 35 (10): 889–97. doi:10.1097/OLQ.0b013e31817dfdb8. PMID 18607310. S2CID 12260211.

[3] McCormack S, Ramjee G, Kamali A, Rees H, Crook AM, Gafos M, et al. (October 2010). "PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial". Lancet. 376 (9749): 1329–37. doi:10.1016/S0140-6736(10)61086-0. PMC 2956883. PMID 20851460.

[1]

[2]

[3]

v t e Microbicides for sexually transmitted diseases
Types	Rectal microbicide Vaginal microbicide
Products	Nonoxynol-9 Tenofovir PRO 2000 BufferGel
Organizations	International Rectal Microbicide Advocates International Partnership for Microbicides Global Campaign for Microbicides Microbicides Development Programme Microbicide Trials Network
Clinical trials	CAPRISA 004 VOICE

PRO 2000

History

Efficacy

References

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