Oxyclozanide
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Names | |
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Preferred IUPAC name
2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide | |
Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.017.186 |
KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C13H6Cl5NO3 | |
Molar mass | 401.45 g·mol−1 |
Pharmacology | |
QP52AG06 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes.[1] Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)".[2]
Sometimes alluded to as "Pentaclosamide": CN101891646.
References
- ^ CID 16779 from PubChem
- ^ Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Conery, Annie L.; Kim, Wooseong; Jayamani, Elamparithi; Kwon, Bumsup; Ausubel, Frederick M.; Mylonakis, Eleftherios (2015). "Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus". PLOS ONE. 10 (4): e0124595. Bibcode:2015PLoSO..1024595R. doi:10.1371/journal.pone.0124595. PMC 4405337. PMID 25897961.
- ^ Oxyclozanide MSDS
Categories:
- PubChem ID (CID) same as Wikidata
- Articles without EBI source
- Articles with changed ChemSpider identifier
- ECHA InfoCard ID from Wikidata
- Articles with changed InChI identifier
- Articles containing unverified chemical infoboxes
- Articles with short description
- Short description matches Wikidata
- Anthelmintics
- Chloroarenes
- Phenols
- Salicylanilides
- All stub articles
- Antiinfective agent stubs