|Trade names||Otosporin, Cortisporin, others|
|Ear drop, ear drop|
|Defined daily dose||not established|
|AHFS/Drugs.com||FDA Professional Drug Information|
Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders. It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone. It is used as an ear drop or eye drop.
The most common side effects include itchiness and a skin rash. Other side effects may include dizziness, hives, anaphylaxis, hearing loss, and headache. Safety in pregnancy and breastfeeding is unclear. The antibiotics work by killing specific types of bacteria while the steroids work by decreasing inflammation.
The combination was approved for medical use in the United States in 1964. In the United Kingdom a 10 ml bottle costs the NHS about £7.45 as of 2019. In the United States the wholesale cost of this amount is about US$50. In 2017, it was the 304th most commonly prescribed medication in the United States, with more than one million prescriptions.
The defined daily dose is not established
Cortisporin was developed by Glaxo Wellcome and was approved by the Food and Drug Administration in 1975. In 1997, the rights were sold to Monarch Pharmaceuticals, a division of King Pharmaceuticals. In 2007, King sold it to JHP Pharmaceuticals. Par Pharmaceutical acquired JHP in 2014. In 2015, Endo International purchased Par.
Society and culture
In David Lazarus' February 4, 2016 LA Times column, a pharmacist recalled a 10 milliliter vial of the drug selling for around $10 in the early 2010s. In 2015, the price was $100, and in 2016, it reportedly was selling for $195. A generic version is priced at $144. The drug is owned by Dublin, Ireland-based Endo International.
Generic name: neomycin sulfate, polymyxin B sulfate, and hydrocortisone
Dosage form: otic suspension (liquid with ear dropper)
Generic name: neomycin sulfate, polymyxin B sulfate, bacitracin zinc and hydrocortisone
Dosage form: Dermatological ointment, drops
- ↑ 1.0 1.1 "Hydrocortisone / neomycin / polymyxin b otic Use During Pregnancy". Drugs.com. Archived from the original on 19 April 2019. Retrieved 19 April 2019.
- ↑ 2.0 2.1 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 9 September 2020.
- ↑ 3.0 3.1 3.2 3.3 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1164. ISBN 9780857113382.
- ↑ 4.0 4.1 4.2 4.3 "Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension - FDA prescribing information, side effects and uses". Drugs.com. Archived from the original on 20 June 2019. Retrieved 19 April 2019.
- ↑ 5.0 5.1 "Hydrocortisone/neomycin/polymyxin b otic Side Effects in Detail". Drugs.com. Archived from the original on 19 April 2019. Retrieved 19 April 2019.
- ↑ "DailyMed - neomycin sulfate, polymyxin b sulfate and hydrocortisone solution". dailymed.nlm.nih.gov. Archived from the original on 26 June 2020. Retrieved 19 April 2019.
- ↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
- ↑ "Neomycin; Polymyxin B; Hydrocortisone - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
- ↑ 9.0 9.1 Lazarus, David (2016-02-04). "Martin Shkreli isn't alone in ripping off patients with crazy drug prices". latimes.com. Archived from the original on 2019-12-30. Retrieved 2016-02-05.
- DailyMed Archived 2020-06-26 at the Wayback Machine
- Pages using duplicate arguments in template calls
- Drugs with non-standard pregnancy category
- Chemical articles without CAS registry number
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs missing an ATC code
- Articles containing unverified chemical infoboxes
- Drugs that are a combination of chemicals
- Webarchive template wayback links
- Combination drugs
- Pfizer brands