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Trade namesCamzyos
Other namesMYK-461
  • 6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione
Clinical data
Drug classCardiac myosin inhibitor
Main usesHypertrophic obstructive cardiomyopathy (HCOM)[1]
Side effectsDizziness, syncope[1]
Routes of
By mouth
External links
License data
Legal status
Chemical and physical data
Molar mass273.336 g·mol−1
3D model (JSmol)
  • CC(C)N1C(=O)NC(N[C@@H](C)C2=CC=CC=C2)=CC1=O
  • InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1

Mavacamten, sold under the brand name Camzyos, is a medication used to treat hypertrophic obstructive cardiomyopathy (HCOM).[1] It is taken by mouth.[1]

Common side effects include dizziness and syncope.[1] Other side effects may include heart failure.[1] Use in pregnancy may harm the baby.[1] It is a cardiac myosin inhibitor.[1]

Mavacamten was approved for medical use in the United States in 2022.[1] It is not available in Europe or the United Kingdom as of 2022.[3] In the United States a month of medication costs about 7,800 USD.[4]

Medical uses

Mavacamten is indicated for the treatment of adults with symptomatic New York Heart Association class II-III obstructive hypertrophic cardiomyopathy to improve functional capacity and symptoms.[1]


It is started at a dose of 5 mg once per day, with long term doses between 2.5 and 15 mg once per day.[1]


Mavacamten was granted orphan drug designation by the U.S. Food and Drug Administration (FDA).[5] It was developed by the MyoKardia, a subsidiary of Bristol Myers Squibb.[6]

Society and culture


Mavacamten is the international nonproprietary name (INN).[7]


  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 "Camzyos- mavacamten capsule, gelatin coated". DailyMed. 28 April 2022. Archived from the original on 3 July 2022. Retrieved 15 May 2022.
  2. "Archive copy". Archived from the original on 2022-11-13. Retrieved 2022-11-29.{{cite web}}: CS1 maint: archived copy as title (link)
  3. "Mavacamten". SPS - Specialist Pharmacy Service. 19 October 2018. Archived from the original on 24 June 2022. Retrieved 12 December 2022.
  4. "Camzyos Prices, Coupons, Copay & Patient Assistance". Archived from the original on 22 May 2023. Retrieved 12 December 2022.
  5. "Mavacamten Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 27 April 2016. Archived from the original on 3 July 2022. Retrieved 29 April 2022.
  6. "Bristol Myers Squibb Completes Acquisition of MyoKardia, Strengthening Company's Leading Cardiovascular Franchise". Business Wire. 17 November 2020. Archived from the original on 29 April 2022. Retrieved 29 April 2022.
  7. World Health Organization (2017). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 78". WHO Drug Information. 31 (3). hdl:10665/330961.

Further reading

External links

External sites:
  • Clinical trial number NCT03470545 for "Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (EXPLORER-HCM)" at