Low grade serous carcinoma of the ovary
| Low grade serous carcinoma of the ovary | |
|---|---|
| Other names: Low grade serous adenocarcinoma of ovary[1] | |
 | |
| Specialty | Oncology, gynecology |
| Usual onset | 40s[1] |
| Causes | Unknown[1] |
| Prognosis | Good if confined to ovary[1] |
| Frequency | Around 5% of serous ovarian cancers[1] |
Low grade serous carcinoma of the ovary (LGSCO) is a type of ovarian cancer that typically presents with pressure symptoms due to its mass effect.[1][2] It may present with ascites.[1] The average age of presentation is around 43 years, 10 years younger than the average age of high-grade serous carcinoma of the ovary (HGSCO).[1] There may be a previous history of a serous borderline tumor.[3] In 2020 the World Health Organization defined it as "a non-invasive, low-grade, proliferative serous epithelial neoplasm".[3]
LGSCO is pathologically distinct from HGSCO, and the cause is unknown.[1] It frequently occurs in both ovaries.[1] Risk factors include not having children and hormone replacement therapy.[2] Older age at first birth, oral contraceptive, and a greater number of children appear associated with a lower risk.[2] When confined to the ovary the outcome is very good.[1] It generally has a better survival rate than HGSCO, though not so good if diagnosed before age 35 years.[2]
Around 80% are diagnosed at an advanced stage.[2] They comprise of around 5% of serous ovarian cancers.[1]
See also
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 WHO Classification of Tumours Editorial Board, ed. (2020). "1. Tumours of the ovary: low grade serous carcinoma of the ovary". Female genital tumours: WHO Classification of Tumours. Vol. 4 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 43–44. ISBN 978-92-832-4504-9. Archived from the original on 2022-06-17. Retrieved 2024-04-16.
- ↑ 2.0 2.1 2.2 2.3 2.4 Babaier, A; Mal, H; Alselwi, W; Ghatage, P (10 February 2022). "Low-Grade Serous Carcinoma of the Ovary: The Current Status". Diagnostics (Basel, Switzerland). 12 (2). doi:10.3390/diagnostics12020458. PMID 35204549. Archived from the original on 6 July 2023. Retrieved 16 April 2024.
- ↑ 3.0 3.1 Grisham, Rachel N.; Slomovitz, Brian M.; Andrews, Nicole; Banerjee, Susana; Brown, Jubilee; Carey, Mark S.; Chui, Herman; Coleman, Robert L.; Fader, Amanda N.; Gaillard, Stephanie; Gourley, Charlie; Sood, Anil K.; Monk, Bradley J.; Moore, Kathleen N.; Ray-Coquard, Isabelle; Shih, Ie-Ming; Westin, Shannon N.; Wong, Kwong-Kwok; Gershenson, David M. (17 August 2023). "Low-grade serous ovarian cancer: expert consensus report on the state of the science". International Journal of Gynecologic Cancer: ijgc. doi:10.1136/ijgc-2023-004610. ISSN 1048-891X. Archived from the original on 30 November 2023. Retrieved 16 April 2024.