LEFTY2

LEFTY2
Identifiers
Aliases	LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2
External IDs	OMIM: 601877 MGI: 2443573 HomoloGene: 2434 GeneCards: LEFTY2
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.12 Start 225,936,598 bp End 225,941,383 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H4 Start 180,720,673 bp End 180,726,668 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myometrium sperm canal of the cervix ascending aorta right coronary artery popliteal artery caput epididymis smooth muscle tissue left coronary artery anterior pituitary Top expressed in mesoderm neural plate primitive streak inner cell mass blastocyst hippocampal formation hippocampus proper floor plate ascending aorta testicle More reference expression data BioGPS n/a
Gene ontology Molecular function transforming growth factor beta receptor binding cytokine activity growth factor activity Cellular component extracellular matrix extracellular region platelet alpha granule lumen extracellular space collagen-containing extracellular matrix Biological process multicellular organism development regulation of apoptotic process positive regulation of pathway-restricted SMAD protein phosphorylation cell growth platelet degranulation regulation of MAPK cascade transforming growth factor beta receptor signaling pathway SMAD protein signal transduction cell development BMP signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7044 320202 Ensembl ENSG00000143768 ENSMUSG00000066652 UniProt O00292 P57785 RefSeq (mRNA) NM_001172425 NM_003240 NM_177099 RefSeq (protein) NP_001165896 NP_003231 NP_796073 Location (UCSC) Chr 1: 225.94 – 225.94 Mb Chr 1: 180.72 – 180.73 Mb PubMed search
Wikidata
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Left-right determination factor 2 is a protein that in humans is encoded by the LEFTY2 gene.

Function

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Further reading

• Tabibzadeh S, Kothapalli R, Buyuksal I (1997). "Distinct tumor specific expression of TGFB4 (ebaf)*, a novel human gene of the TGF-beta superfamily". Front. Biosci. 2: a18–25. doi:10.2741/a158. PMID 9230066.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.