Polygeline

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Polygeline
Names
Trade namesHaemaccel[1]
Other namesProcessed bovine gelatin
Clinical data
Drug classPlasma expander
Main usesHypovolemic shock[1][2]
Side effectsAnaphylaxis[1][2]

Polygeline, sold under the brand name Haemaccel among others, is a type of intravenous colloid used to treat hypovolemic shock.[1][2] This includes cases due to bleeding, fluid loss, and pancreatitis.[2][3] It is given by injection into a vein.[4]

Side effects may include anaphylaxis, with wheezing, low blood pressure, and hives; which occurs in about 0.8% of cases.[1][2][5] It does not alter cross matching of blood.[1] It may be used in people with kidney problems.[1] It is made from gelatin from cow bones.[1][2] It also contains sodium chloride, potassium chloride, and calcium chloride.[3]

Polygeline was first made in 1962 by Schmidt-Thome.[1] While used in Europe, it is not available in the United States.[6] It is on the World Health Organization's List of Essential Medicines as an alternative to dextran 70.[7] They are not very expensive as of 2005.[8]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Srivastava, RP (December 2020). "Place of Polygeline in Fluid Resuscitation: Focus on Hypovolemic Shock". Indian J Surg. 82: 1229–1234. doi:10.1007/s12262-020-02221-y.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Kong, Fabian (2000). "Haemaccel (Polygeline) Reactions Anaphylaxis or Anaphylactoid?". The Australian Journal of Hospital Pharmacy. 30 (3). doi:10.1002/jppr2000303107. Archived from the original on 16 September 2023. Retrieved 13 September 2023.
  3. ↑ 3.0 3.1 "Haemaccel". EMC. Archived from the original on 16 September 2023. Retrieved 13 September 2023.
  4. ↑ "Polygeline". WHO. Archived from the original on 4 June 2023. Retrieved 13 September 2023.
  5. ↑ Barron, Michael (May 2004). "A systematic review of the comparative safety of colloids". Arch Surg. 139 (5): 552. doi:10.1001/archsurg.139.5.552. PMID 15136357.
  6. ↑ McNeil, E. L. (6 December 2012). Airborne Care of the Ill and Injured. Springer Science & Business Media. p. 138. ISBN 978-1-4684-8679-7. Archived from the original on 16 September 2023. Retrieved 13 September 2023.
  7. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
  8. ↑ Lake, Carol L.; Booker, Peter D. (2005). Pediatric Cardiac Anesthesia. Lippincott Williams & Wilkins. p. 638. ISBN 978-0-7817-5175-9. Archived from the original on 16 September 2023. Retrieved 13 September 2023.

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