Dextran 70

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Dextran 70
Names
Trade namesRescueFlow, others
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
use
intravenous
Defined daily dosenot established[1]
External links
AHFS/Drugs.comMonograph
Legal
Legal status
Chemical and physical data
Molar mass70,000 Da

Dextran 70 is a type of fluid given by injection into a vein to expand blood volume.[2] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[3] However, it does not carry oxygen.[3]

Common side effects include vomiting, fever, and joint pains.[3] Other side effects include allergic reactions and poor blood clotting.[2] It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder.[3] It is not recommended during pregnancy.[4] It works by pulling fluid from the extravascular space into the blood vessels.[3]

Dextran 70 was approved for medical use in 1947.[5] It is on the World Health Organization's List of Essential Medicines.[6] The wholesale cost in the developing world is about US$4.10–5.25 per 500 ml.[7] In the United Kingdom this dose costs the NHS about 57.00 pounds.[4] In the United States it costs about $25–50 per dose.[8] It comes in either sodium chloride solution or glucose solution.[3]

Dosage

The defined daily dose is not established[1]

References

  1. 1.0 1.1 "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 15 September 2020. CS1 maint: discouraged parameter (link)
  2. 2.0 2.1 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 248, 257–58, 279, 287. hdl:10665/44053. ISBN 9789241547659.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 "Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016. CS1 maint: discouraged parameter (link)
  4. 4.0 4.1 British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 9780857111562.
  5. BeMiller, James N.; Whistler, Roy L. (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 9780080926544. Archived from the original on 2017-01-03. CS1 maint: discouraged parameter (link)
  6. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  7. "Dextran 70 6% in Sod. chloride 0.9%". International Drug Price Indicator Guide. Retrieved 8 December 2016. CS1 maint: discouraged parameter (link)
  8. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 167. ISBN 9781284057560.

External links

Identifiers:
  • "Dextran 70". Drug Information Portal. U.S. National Library of Medicine.