Dextran 70

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Dextran 70
Names
Trade namesRescueFlow, others
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
use
intravenous
Defined daily dosenot established[1]
External links
AHFS/Drugs.comMonograph
Legal
Legal status
Chemical and physical data
Molar mass70,000 Da

Dextran 70 is a type of fluid given by injection into a vein to expand blood volume.[2] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[3] However, it does not carry oxygen.[3]

Common side effects include vomiting, fever, and joint pains.[3] Other side effects include allergic reactions and poor blood clotting.[2] It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder.[3] It is not recommended during pregnancy.[4] It works by pulling fluid from the extravascular space into the blood vessels.[3]

Dextran 70 was approved for medical use in 1947.[5] It is on the World Health Organization's List of Essential Medicines.[6] The wholesale cost in the developing world is about US$4.10–5.25 per 500 ml.[7] In the United Kingdom this dose costs the NHS about 57.00 pounds.[4] In the United States it costs about $25–50 per dose.[8] It comes in either sodium chloride solution or glucose solution.[3]

Dosage

The defined daily dose is not established[1]

References

  1. 1.0 1.1 "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 15 September 2020.
  2. 2.0 2.1 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 248, 257–58, 279, 287. hdl:10665/44053. ISBN 9789241547659.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 "Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016.
  4. 4.0 4.1 British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 9780857111562.
  5. BeMiller, James N.; Whistler, Roy L. (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 9780080926544. Archived from the original on 2017-01-03.
  6. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  7. "Dextran 70 6% in Sod. chloride 0.9%". International Drug Price Indicator Guide. Retrieved 8 December 2016.
  8. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 167. ISBN 9781284057560.

External links

Identifiers:
  • "Dextran 70". Drug Information Portal. U.S. National Library of Medicine.