Dermatopathic lymphadenopathy

Dermatopathic lymphadenopathy
Other names	Dermatopathic lymphadenitis
Micrograph showing dermatopathic lymphadenopathy with the characteristic paracortical histiocytosis and melanin-laden macrophages. H&E stain.
Specialty	Dermatology

In pathology, dermatopathic lymphadenopathy, is lymph node pathology due to skin disease.

Cause

Also known as lipomelanotic reticulosis or Pautrier-Woringer disease, represents a rare form of benign lymphatic hyperplasia associated with most exfoliative or eczematoid inflammatory erythrodermas, including pemphigus, psoriasis, eczema, neurodermatitis, and atrophia senilis.

Diagnosis

Dermatopathic lymphadenopathy is diagnosed by a lymph node biopsy. It has a characteristic pattern of histomorphology and immunohistochemical staining:

• Paracortical histiocytosis
• Melanin-laden macrophages
• Eosinophils
• Plasma cells (medulla of lymph node)

Differential diagnosis

• Cutaneous T cell lymphoma
• Hodgkin's lymphoma
• Melanoma

Treatment

The treatment is based on the underlying cause.

See also

• Skin disease
• List of cutaneous conditions

External links

• Dermatopathic lymphadenitis - pathconsultddx.com.