Carbazole 1,9a-dioxygenase
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| Carbazole 1,9a-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.22 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Carbazole 1,9a-dioxygenase (EC 1.14.12.22, CARDO) is an enzyme with systematic name 9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction
- 9H-carbazole + NAD(P)H + H+ + O2 2'-aminobiphenyl-2,3-diol + NAD(P)+
Carbazole 1,9a-dioxygenase catalyses the first reaction in the pathway of carbazole degradation.
References
- ^ Nam JW, Nojiri H, Noguchi H, Uchimura H, Yoshida T, Habe H, Yamane H, Omori T (December 2002). "Purification and characterization of carbazole 1,9a-dioxygenase, a three-component dioxygenase system of Pseudomonas resinovorans strain CA10". Applied and Environmental Microbiology. 68 (12): 5882–90. Bibcode:2002ApEnM..68.5882N. doi:10.1128/aem.68.12.5882-5890.2002. PMC 134387. PMID 12450807.
- ^ Gai Z, Wang X, Liu X, Tai C, Tang H, He X, Wu G, Deng Z, Xu P (April 2010). "The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5". PLOS ONE. 5 (4): e10018. Bibcode:2010PLoSO...510018G. doi:10.1371/journal.pone.0010018. PMC 2848856. PMID 20368802.
External links
- Carbazole+1,9a-dioxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
