Alkb homolog 1, histone h2a dioxygenase

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ALKBH1
Identifiers
AliasesALKBH1, ABH, ABH1, ALKBH, alkB, hABH, alkB homolog 1, histone H2A dioxygenase
External IDsOMIM: 605345 MGI: 2384034 HomoloGene: 4393 GeneCards: ALKBH1
EC number4.2.99.18
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039506
NM_006020

NM_001102565

RefSeq (protein)

NP_006011

NP_001096035

Location (UCSC)Chr 14: 77.67 – 77.71 MbChr 12: 87.47 – 87.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AlkB homolog 1, histone H2A dioxygenase is a protein that in humans is encoded by the ALKBH1 gene. [5]

Function

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100601 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079036 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: AlkB homolog 1, histone H2A dioxygenase". Retrieved 2018-07-12.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.